A.C.O.G. Poster Presentation:
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ACOG ABSTRACT:
Novel Medical Endometriosis Protocol offers alternative to TAH BSO and Hemicolectomy in Confirmed Stage IV Disease
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[Editor]: these medications blocked estrogens and reversed even the most severe endometriosis.
Case Report:
A 31-year old woman with Stage VI endometriosis unresponsive to leuprolide acetate had a total abdominal hysterectomy and bilateral salpingo-oophorectomy 5 years earlier. Because of pain she was scheduled for a hemicolectomy at John Hopkins Hospital. The novel USDR protocol focused on bio-chemical mechanisms:
(1) lowering estradiol to immeasurable levels and reversing
(2) the high Sex Hormone Binding Globulin (SHBG) and
(3) low free testosterone.
The F.D.A. medications consisted of weekly injections of Nandrolone (Organon –Holland) and of Stanozolol (Lundbeck-Denmark).
Nandrolone’s unique properties are its
(1) strong affinity for the Androgen-Receptor on the cell;
(2)displacing testosterone and estrogens. (3) Its progestational activity prevents aromatization of testosterone to estradiol and prevents conversion of natural testosterone to dihydrotestosterone by 5-alpha reductase.
Because these medications have similar but stronger biochemical effects on SHBG and free testosterone then do danazol or gestrinone, it was hypothesized that their combination would better suppress endometriosis and create an atophic endometrial lining.
Results:
Stanozolol lowered SHBG by 80% (210 nmol/L to 20 nmol/L); with the addition of nandrolone, the Free Androgen Index increased from .01 to .15.
[Editor]: By increasing by more than 10 fold the affinity of Androgens affixed to the cell receptor , no estrogens could get through.
Conclusion:
The patient discontinued daily pain medication, remained amenorrheic (no menstrual periods), delayed surgery and resumed marital relations. Her bone density and weight remained stable while she increased her lean body mass. She reported neither dyspareunia nor hirsuitism. Laboratory tests revealed increased red blood cell count and normal liver functions. The patient has remained on continuous therapy for 8 years with no intent to discontinue either medication.
Hypothesis:
The author theorized that SHBG. medications successfully blocked both the cell Androgen Receptor and the liver production of SHBG., Thereby, interrupting the continuing propagation of endometriosis via estrogens and Endocrine Disrupting Chemicals (EDCs).
For Information
Contact the Benefit Manager about the USDR PROTOCOL for WOMEN's ISSUES:
Novel Medical Protocol offers Alternative to HYSTERECTOMY AND OVARIAN REMOVAL and
Contact
Edward M Lichten, M.D.
Assistant Clinical Professor, Wayne State College of Medicine
555 South Old Woodward Avenue Suite #700
Birmingham, MICHIGAN 48009
Telephone: 1.248.593.9999
Email: [email protected]
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