The Richest Men in the World, top executives of Google®, Genetech®, Apple® and CALICO®
are spending billions on WELLNESS while Use this APP to complement, reduce or eliminate expensive prescription drugs that limit therapies to treat symptoms. You may find the information contained within both interesting and beneficial.
**PREVENTATIVE MEDICINE**
Alternative and holistic medical practitioners check an extensive battery of laboratory tests to diagnose potential disease states before symptoms manifest. The most practical testing is quite affordable (between $100 and $500) using our 60% discount--and you can order the tests before seeing the doctor in most states. We often order a Coronary Artery Calcium Score (C.A.C.S.) in men over 40 years of age, women over 60 and those with major inflammatory disease states. These simple, alternative, medically proven, safe prescription and OTC treatment should be preventative BEFORE he/she shows diabetes, heart disease or chronic inflammation. Your physician will first compile and personally reviews your complete medical history, medical diseases, surgeries and injuries, medication and supplementation. Key laboratory testing may help your physician identify and treat the imbalances.
PARADIGM SHIFT>:
We see disease as the step-by-step destructive and inflammatory effects of man-made environmental toxins on mankind: plastics, pesticides and hormones.
1. Lundfeld stated "This decline in endocrine function involves: A decrease of testosterone, dehydroepiandrosterone (DHEA), estrogens, thyroid stimulating hormone (TSH), growth hormone (GH), insulin-like growth factor-1 (IGF-1), and cortisol. Disease is concomitant with an increase of LH and FSH and SHBG;
2. We observe a decrease in bioavailable testosterone in both sexes (see SHBG, low[T, FAI).
3. Replacing these hormones to youthful serum levels may in some way reduce the risk of developing diseases.
READ the . abbreviated reports/ breakthroughs in medical treatments on many topics listed within.
Alcoholism costs the United States $225 billion dollars, 88,000 deaths, 1.5 million auto-accidents and two-thirds of jail admissions. Alcoholism may become a more treatable disease using a program of oral Antabuse®/disulfiram followed by implanted disulfiram pellets. All alcoholic men are testosterone deficient. Women are also low in androgens with elevated estrone and elevated SHBG. Treatment of these hormonal imbalances may be a new key to improving their Quality of Life and their potential metabolic recovery.
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BACKGROUND:
Alcoholism, also known as alcohol use disorder (AUD), is a chronic dependency disease characterized by the consumption of alcohol at a level that interferes with physical and mental health- affecting 14 million adults in the US and 250 million worldwide. The biggest difference between alcohol abuse and alcoholism is that addiction is a disease that affects and interferes with all areas of a person's life. Excessive drinking is defined as more than 8 drinks per week for women and 15 or more for men. Researchers defined a drink as just 5 ounces of wine, 12 ounces of beer or 1.5 ounces of spirits. Alcoholism AUD affects more women than men. For hundreds of years, attempts to prevent and stop alcoholism from developing, worsening and destroying the person’s life have been dismal failures.
NEW INFORMATION
• Psychology has discovered a tight relationship between antisocial personality disorder (ASPD) and alcoholism. 68% of ASPD have AUD. Approximately 20% of alcoholic have personality disorders and another 20% have ASPD. Secondarily, men with PD have lower levels of total and free testosterone.
• Biomarkers. Alcoholics have hormonal dysregulation that occurs prior to and worsen with the diagnosis of alcoholism. In men, the testes size, sperm count, total testosterone [TT] and sexual frequent are decreased as is the bioavailable testosterone measured as the Free Androgen Index [TT/SHBG]. Increased sex-hormone binding globulin (SHBG) isolates alcohol as a man-made environmental estrogen toxin (xenoestrogen) and systemic inflammatory agent. The laboratory tests of FSH and total estradiol [E2] may further elucidate the degree of the hormonal aspects of disease. Elevated FSH, elevated SHBG and low progesterone have been linked to alcohol dependency. Higher FSH implies both lower total testosterone and decreased Free Androgen index(FAI)/ bioavailable testosterone.
• Future Risks. Liver damage and cirrhosis, heart, brain disease, and for women, increased incidence of breast cancer.
NEW TREATMENTS
• Both oral disulfiram/ Antabuse® and naltrexone injections (Vivitrol®) are FDA approved for alcoholism. The cost at the pharmacy of Vivitrol® is $1300. for 380mg/ month.
• Disulfiram/ Antabuse® has been an effective deterrent, albeit, it is oral and alcoholics stop the medication to drink. Attempts to formulate disulfiram implantation pellets have not been successful, we believe, because the dosage of 1 gram/ implant/ for 6 to 12-months has been too low. We calculated and implemented a test protocol with two grams of disulfiram every two weeks for 6 weeks. The 2 gm pellets were then implanted every month for 3 months. With these dosages, measurement of the metabolites of disulfiram reach therapeutic levels.
• Naltrexone has been suggested to lower the occurrence of binge drinking. Oral dosage is 100 to 150 mg/ day, roughly double that of an implant or anabolic steriods. See Deca-durablin®/ nandrolone AIDs articles using weekly injections. In the U.S., brand name nandrolone and oxandrolone are more easily available abroad and limited to select compounding pharmacies. AIDs patients are paying 10 times more for Anavar® while it is illegal for U.S. citizens to import Deca-durabolin®/ nandrolone. Nandrolone is available through compounding pharmacies: check http://www.USDOCtOR.ONLINE for additional information. AIDs patients petitioned the US government for access to nandrolone coverage by Medicaid and were denied.injection. Implants of 200mg to 2 grams have been manufactured. Implants usually last twice as longer as injections. Therefore, 1 to 2 grams of naltrexone every 6 to 10-weeks would be in a comparable, therapeutic dosage range.
FOR ADDITIONAL INFORMATION |
There are 1.1 million people affected, annual cost is $23 billion in AIDs medication and medical care. Lifetime expenditure is estimated at $400,000. The FDA approved manufacturer, of Anavar®/oxandrolone, promises to not charge more than $15,000 per individual/ $30 per 20mg tablet; estimated at $10 billion dollars per year. POTENTIAL SAVINGS for AIDs patients include less costs and a
better quality of life with Oxandrolone weakened sex performance but lowered SHBG.
Alzheimer's Disease is a progressive disorder that causes brain cells to waste away, atrophy (degenerate) and die. Alzheimer's disease is the most common cause of dementia which is a continuous decline in thinking, behavioral and social skills that disrupts a person's ability to function and live independently. Alzheier's disease accounts for 60 to 80 percent of cases of dementia. More than 200,000 cs occur in the 40's and 50's: this is called early onset dementia. An article in Current Drug Targets states "Observational studies generally showed that low endogenous testosterone levels were associated with poor cognitive performance in healthy elderly men. Testosterone substitution exerted positive effects on certain cognitive domains in normal and hypogonadal elderly men. In conclusion, testosterone may influence cognitive function in elderly men and its substitution may be considered in men with cognitive impairment and testosterone deficiency." Research by the USDOCTOR Research Foundation finds not only low testosterone but, elevated Sex hormone binding globulin (SHBG) in these men and women. This makes ALZHEIMER'S DISEASE another autoimmune disease that might respond to hormonal manipulation similar to how the editor treat Crohn's disease.
NEW RESEARCH
We are in the process in our International Bio-Fit® laboratory of measuring the individual's immune status cytokines, Estrogen Receptors beta and alpha before prescribing medication. This is done by extracting T-lymphocytes from a routine venous blood draw from the arm, growing the cells in test tubes, and incubating them with FDA approved medications. This will determine which combination of medications might be the 'best fit' treatment: the treatment that best reduces inflammation everywhere in the body. |
EPO drug therapy such as Epogen®/erythropoietin for dialysis patients costs the
U.S. $6 billion/year.
100mg of Deca-durabolin®/nandrolone given as an intramuscular injection weekly reduces the need for EPO [by 50%] and improves the quality of life.
In developing poor countries,
Deca-Durabolin®/ nandrolone replaced EPO as the first-line drug of choice. When nandrolone is combined with EPO, the dose of EPO routinely is halved. The addition of stanozolol may reduce the need for EPO further. Adding back testosterone for men incur further gain in hemoglobin say Yen & Jaffee [2019] page 363
Reproductive Endocrinology.
POTENTIAL SAVINGS are billion dollars in medication costs while realizing improved quality of life.
Arthritis costs cost $127.8 billion/year in the U.S; $80.8 billion in medical care and $47 billion in lost earnings in 2014. Reduction in use of pain and NSAIDs medication for osteoarthritis can occur with a mixture of anabolic steroids.
Australian news [Hassager C. University of Copenhagen, Denmark, 2009] reports that "nandrolone is used to treat osteoporosis (loss of bone tissue)"; it stimulates type III collagen synthesis; possibly an uptake of synovial fluid in joints. Nandrolone has been shown to improve quality of life.
Note that Rheumatoid Arthritis is an autoimmune disease that affects the entire body. It is a systemic disease as Crohn's Disease, Endometriosis, Diabetes, and Lupus Erythematosus. Scroll down to
Rheumatoid Arthritis to read more about this different disease and how it is responding to mixtures of androgenic-anabolic steroids (AAS).
Asthma affects 25 million in the US, mostly black and hispanic minorities. Average annual cost is $3,300 per individual; U.S. cost is $89 billion.
Schrader reported that intravenous ascorbic acid (Vitamin C) and magnesium were able to reduce the need for asthma medication and emergency room visits by half in a long-term study.
Nebulizers of glutathione and
DHEA-S have been used to improve breathing even in those with cystic fibrosis. Glutathione may, however, induce bronchiospasm in mild asthma patients--Majid Ali, M.D. recommends that the patients need to be well hydrated before therapy.
NEW RESEARCH: Males have more asthma as teens and then the 'switch' is to prevalence for women.
Low testosterone in young men is statistically significant as is high SHBG protective for women. Results correlation of low Free Androgen Index in men and increased inflammatory T-lymphocytes in the Bio-Fit laboratory analysis is planned for later this year.
Atrial fibrillation is the rapid stimulation of the atria of the heart to contract. Rapid contractions prevent the atria from emptying, so that, blood can clot in the atria and break off and cause cerebral strokes Although the incidence is small, 4.4 per 100-years, stroke is a major cause of death. One-quarter of all strokes may be related to these blood clots so the internists are quick to add a anti-coagulant medication. A baby aspirin daily or prescription Aggrenox® at $60 per month is effective and most cost effective. Eliquis® (apiaban) may be the best of the expensive commonly prescribed, most advertised and over prescribed medications: it goes off patent in 2023. US costs are $472/month; Canadian costs $56.
NEW TREATMENT
The author prescribes the combination of stanozolol and metformin [Melon I, BMJ. 1971]. This combination is as effective as streptokinase at dissolving even venous thrombosis without any need for Protime or Partial Thromboplastin Time monitoring. This stanozolol/metformin combination can normalize even an abnormal Plasminogen Activator Inhibitor-1 laboratory test because its anti-clotting mechanism is different from the other drugs mentioned. Stanozolol is available from compounding pharmacies in the US.
The key to use of BHRT is to
target the doses to physiologic reference ranges administered in a daily dose relieving menopausal symptoms in peri/menopausal women. This cannot be done without measuring the FSH/LH, estradiol, testosterone and Sex Hormone Binding Globulin. Compounded estradiol cream costs $50 per month; Brand Premarin® and Estrace® can cost in excess of $350 per month. MASSIVE COST SAVINGS: Compounded testosterone costs $80; brand Androgel® costs $620 per month. Compounding saves 25 to 75% over manufactured pharmaceutical drug costs.
More than 500,000 U.S. women have a hysterectomy each year (2008) at a cost of $9.5 billion dollars. Add the half billion dollars in pre-operative use of Lupron®/luprolide acetate. One-third of hysterectomies are due to recurrent uterine bleeding; many are related to leiomyomata (fibroids). When questioned at the
April 2014 American College of Obstetricians and Gynecologists Annual Meeting, the editor reports mixtures of anabolic steroids used to treat and reverse endometriosis
(described in the PUBMED.org article) could have other uses.
NEW TREATMENT
it could reduce bleeding cases scheduled for hysterectomy and reduce the use of luprolide acetate resulting in savings of billions of dollars/annually.
Women who have been treated for breast cancer either are menopausal or usually become menopausal due to chemotherapy. They may suffer with intense hot flushes and are banned from using significant doses of estrogen replacement due to fear of increased recurrences.
High SHBG was found in cytosol estrogen receptor positive patients. Europeans recognize that stanozolol does not raises estrogen levels; they use it for cancer prophylaxis and recognize that this SHBG lowering drug therapy can be combined with non-aromatizable nandrolone to alleviate the post-oophorectomy/ chemotherapy menopausal symptoms.
NEW RESEARCH: There are two biomarkers: first, Free Androgen Index (TT and SHBG); second Estrogen Receptor beta and alpha and the cytokines. From our Bio-Fit laboratory, we find high levels of Etrogen Receptor-beta. Estrogen Receptor beta can be measured in our Bio-Fit laboratory. It has been a focus of Breast Cancer Research. Future IRB will seek to determine if any of the agents can reestablish normal ER-beta/ ER-alpha ratio and cytokines is a future therapy/ protocol for Breast Cancer patients.
Breast cysts occur commonly when there are fluctuations of hormones in teens and pre- and post-menopausal women. Aspiration is often done first. Aspiration is a simple office procedure, and hormone therapy (oral contraceptives,
danazol or mixed androgen injections) will suppress further cyst formation.
OLD TREATMENT: The Editor has seen that applying topical Lugol's iodine solution may shrink the cyst in a matter of a few days; however, she still needs to see the doctor for evaluation and treatment.
Cholesterol is a symptom, not a disease. Anyone call
order this laboratory test on-line.
Screening blood lipids is recommended by the US Preventive Service Task Force only every 5 year after 35 years of age in men and 45 years of age in women. John Hopkins physicians state that a normal Coronary Artery Calcium Score, a $150 test, almost always eliminates any need to treat with a statin. Furthermore, a Coronary Artery Calcium Score (CACS) score of zero need not be repeated for 10 years and could reduce routine cardiology testing and screening for coronary artery disease and visits significantly. More than two-thirds of patients on statins do not qualify based on the Rose Criteria (1991); their C.A.C.S. is less than 100 or they are
older than 70 years of age. Cost savings of $2 billion dollars in medications and redundant cardiology testing may be realized. The February JAMA 2014 lead article stated that the ACA and AMA agreed that
simple statins are considered appropriate therapy: adding on additional drugs were deemed unnecessary. Merck tried more than 20 years ago to add-back Coenzyme-Q10 but, the FDA nixed the idea. Statins deplete Coenzyme Q10. Dr Okuyama, of Nagoya City University, Japan, said: “We have collected a wealth of information on cholesterol and statins from many published papers and find overwhelming evidence that these drugs accelerate hardening of the arteries and can cause, or worsen, heart failure. I cannot find any evidence to support people taking statins and patients who are on them should stop.
NEW RESEARCH: The newest research is looking at
treating inflammation as a key to preventing inflammation. They are attempting to block cytokine IL-1-beta. At the bio-Fit laboratory, we have identified mixed-AAS (androgenic-anabolic steroids) that do just that and are individualized per the patient.
The Oxford Dictionary defines CONTRACEPTION as the deliberate use of artificial methods or other techniques to prevent pregnancy as a consequence of sexual intercourse. The major forms of non-hormonal artificial contraception are BR>
barrier methods, of which the
* most common is the condom,
* contraceptive vaginal creams, the
* intrauterine Paragard® device using copper, and
* mechanical tubal ligation and vasectomy.
Man-made hormonal forms of contraception include the
Nexplanon(*) hormonal implant and
*injections which contains synthetic sex hormones that prevent ovulation in the female.
>>>Except for barrier methods, the man-made hormone derivatives include ethinyl-estradiol, progestins and testosterone derivatives such as gestrinone. These interfere with natural Hypothalamic-Pituitary-Ovarian/ Gonadal Axis production of natural estradiol, testosterone and oxytocin. These hormonal manipulations are linked to more depression, weight gain, and interference with natural oxytocin release and subsequent poor orgasm in women. Natural hormones and derivatives of dihydrotestosterone have been combined to suppress ovulation and sperm counts. Male contraception usually adds a synthetic progestin: its effect on libido is often negative.
SUMMARY: We find that the Paragard® copper IUD works best for a woman who needs contraception, but does not want a loss of libido; and that the intermittent use of the mixed-androgenic anabolic steroid reduces menstrual flow, associated menstrual pain and enhanced libido and orgasmic responsiveness.
In 2008, the annual costs for Crohn's Disease and for Ulcerative Colitis were between $7,000 and $14,000, individually. This estimate has increased from $6 billion dollars in 2007 to $20 billion dollars in 2020 as the disease has spread throughout the world. Crohn's medications are among the most expensive in the US.
deficient in DHEA and testosterone. Anabolic steroids can supplement and even reduce the use of biologic drugs such as Humira®/adalimumab; potentially saving billions and many of the 200,000 colon resection. For some, human growth hormone proves beneficial. The Bio-Fit® Research Program has reduced or eliminated the need for Humira®/ adalimumab, Remicade®/ infliximab, Imuran® and high dose steroids; many report an improved quality of life and some the ability to return to work even with Short Bowel Syndrome. The identification of low testosterone and elevated sex hormone binding globulin(SHBG) is the first biomarker of autoimmune disease, reports the author.
The Estrogen Receptor beta drop has a 90% association with active disease flair in our Bio-Fit® laboratory. Go to
Free Androgen Index (FAI) for instruction on performing this laboratory test: FAI is calculated as total testosterone divided by SHBG.
FECAL TRANSPLANT: Although initial reports suggested that putting a more 'normal' bacteria in the individual's GI tract would be beneficial, Gil Melmed, MD at Cedars-Sinai claimed a measly 37% positive response; barely better than placebo.
Depression is the symptom of many endocrine deficiencies: thyroid, adrenal, diabetes, menopause,
andropause (low-T) and low levels of growth hormone and vitamin D. The Editor suggests drawing a
H.I.S. or H.E.R. panel and first correcting the biological hormonal deficiencies. This also includes steps to bring the Sex Hormone Binding Globulin into normal range. In Germany, 5-HTP, GABA and especially SAM-e is prescribed in lieu of Prozac-like drugs. Of note, depression in
peri- and postmenopausal women responds better to testosterone and estrogen than estrogen alone. Dysregulation of oxytocin is also involved.
OLD TREATMENT: Sherwin and Gelfand in Montreal published data 25 years ago that menopausal women responded best to a combination of estrogen and testosterone marketed under the name EstraTest®/ Covaryx®.
Diabetes costs the U.S. almost $300 billion dollars annually. Harvard's
EL Ding established that all diabetic adult men are hypogonadal (low testosterone).
D. Kapoor used 200mg testosterone injections every two weeks to improve glycemic control by almost 0.2%.
Bayer pharma group used Nebido® (long-acting testosterone injection) to lower Hgb1c by 0.2% over one year. Lowering glycogenated hemoglobin (hemoglobin A1c) by 2% which we have documented with mixed-AAS (3 drug therapy) reduces complications of diabetes statistically by 70%, potentially saving men from dialysis, amputations, blindness, heart attacks and strokes. Estimated cost savings are tens of billions of dollars annually. Better control can be achieved by mixing two additional anabolic steroids in the weekly testosterone injections. A reduced dosage schedule may be applicable for women.
Metformin remains the first drug of choice. All diabetic suffer with
vitamin (A, D, B12, choline) and
mineral deficiencies.
D: DRUGS, RECREATIONAL USE and ABUSE
Dysmenorrhea refers to menstrual pain that interferes with family life and work/school. It affects 2.5 million women in the United States. The pain is caused by spasms that narrow the cervical (womb) opening. After
standard treatment with NSAIDs (ibuprofen) and oral contraceptives, a new study suggest a link to the Estrogen Receptors and dysfunction of the immune system. If the pain persists, a laparoscopy is used to detect endometriosis.
Transection of the utero-sacral nerves, a surgery developed by the Editor, may offer temporary pain relief (proving the pain is not psychosomatic) but, the long term effectiveness is not established. The new treatment protocol developed by the Editor utilizes the hormonal- immunity connection and atrophy of the endometrium
utilizing low doses of mixed androgenic-anabolic steroids (mix-AAS) weekly injection for endometriosis. This treatment has proven effective before surgical intervention and after failure of standard medical and surgical therapy. In cases of chronic pelvic pain related to hormonal issues, the injections usually and quickly bring relief within 1 to 8 weeks.
SUMMARY:
ACOG Practice Bulletin Summary.
The key to desire and arousal is the man's
free androgen index. This is more than just his total testosterone; it is total testosterone divided by the transport protein, Sex Hormone Binding Globulin (SHBG). Normal young men have a ratio of 1.0; 50 year-old men average only one-third. While testosterone creams and gels can temporarily raise testosterone, the body soon responds by making more SHBG. We use testosterone creams with an estrogen blocker and add a capsule that blocks the ability of the body to make SHBG. Then, adding a sildenafil/ Viagra®-like tablet with oxytocin may recreate the sexual excitement experienced as a young adult woman. Women can use one-half of this patented tablet and one-tenth the dose of testosterone. More men are self-injecting themselves with testosterone or a mixture of anabolic steroids and finding this to be easy. They save almost $400 per month with testosterone injections versus Androgel® ($200 Androgel® per month; $44.50 for Testosterone cypionate 2000 mg for 10 weeks).
and Dysmenorrhea/ menstrual pain. More than 100,000 women have a hysterectomy in the U.S. each year at a cost of $9.5 billion dollars and the preoperative use of luprolide acetate adds an additional annual cost of half of a $1 billion dollars. One-third of hysterectomies are due to endometriosis, bleeding, and pelvic pain.
Endometrial ablation is used for the symptom of heavy menstrual bleeding. The use of a mixture of anabolic steroids could reduce these cases by almost half and reduce the use of Lupron®/luprolide acetate resulting in total savings of $2.5 billion dollars. To understand dosing read the Editor's presentation at the
Annual Meeting of the American College of Obstetricians and Gynecologists 2014 in Chicago.
The use of nutraceuticals,
L-carnitine (Caritor®), Coenzyme Q10,
DHEA and minerals have been shown to improve ejection fraction.
Human Growth Hormone,
testosterone and the other anabolic steroids have allowed our case report who was refused heart transplant at 39 years of age to live a normal life for almost 11 years. His ejection fraction increase from 15 to 45% (normal) as measured by cardiologists. This combined approach, adding mixed androgenic-anabolic steroids (mix-AAS) to standard heart medication, may provide a beneficial adjunct to not only 1000 annual heart transplants but, the millions in failure at home.
Sleep disturbances due to increased sympathetic activity is present in CFS patients only at night. This results in
significant derangement of sleep leading to imbalances of all the bio-identical hormones. Case reports show that many men and women have returned to normal function after multiple bio-identical hormone treatments without human growth hormone. [See Bennett- Fibromyalgia]
The Editor finds that adding back the gambit of natural hormones quickens the recovery over hGH alone.
RM Bennett, M.D., Professor and Chairman at the University of Oregon identified that women with fibromyalgia had lower levels of Somatomedin-C (insulin like growth factor-1 (IGF-1)); the marker for human growth hormone(hGH). Nine months of
hGH therapy resulted in significant improvement in 75% of volunteers. The cause, however, of low hGH is poor sleep. This needs to be addressed from a
multi-factorial and hormonal perspective. Our Case Reports show that replacement of all the other bio-identical hormones to physiological mean levels is necessary before suggesting or beginning hGH.
The uneven distribution of stomach cancer in North Wales compared with the distribution of land fills with high organic matter content. JA Myers [
Metabolic Aspects of Health 1979] postulated that trace mineral deficiencies are linked to overuse of tillable soil. Some researchers suggest
selenium deficiency may play a significant part in some regions of the world. The Chinese "findings indicate that
vitamin and mineral supplementation of the diet of Linxian adults, particularly with the combination of beta carotene, vitamin E, and selenium, may effect a reduction in cancer risk in this population."
NEW RESEARCH: Elevated levels of Sex Hormone Binding Globulin (SHBG) are noted in
Gastric and
colon cancer.
At the inter-cellular immunity level, the estrogen receptors beta is involved in the progression and deterioration of
gastric cancer.
NEW BIOMARKER TESTING: Using the Bio-Fit® laboratory, an in-vitro analysis may identify hormonal drugs that improve immunity by stabilizing the Estrogen Receptor beta and the cytokines, TNF-alpha; of T-lmphocytes. The therapies are begun as adjunct therapy. This technique would be applicable to colon adenocarcinoma as well gastric cancer Crohn;'s and Ulcerative colitis Inflammatory Bowel Disease (IBD).
Four in ten Americans suffer with G.E.R.D. One hundred million prescriptions cost the U.S. $14 billion dollars. This is based on a common misconception that patients with G.E.R.D. have too much acid. The truth is that the stomach needs a pH (acid) level of 2 to close the upper sphincter to the esophagus.
If there is a low level of acid on the Heidelberg Test, taking 1-2 Betaine HCl capsules at the start of the meal, and 2 digestive enzyme capsules at the end of the meal is a more natural means to normalize digestion, less G.E.R.D. The pharmaceuticals block acid production and open the lower sphincter to the small bowel; normal digestion is interrupted. If the gallbladder is absent or dysfunctional, ox bile is added. This saves prescription medications for the much smaller, non-responsive population and upwards of $5 billion dollars in medication costs, notwithstanding the
F.D.A. warnings about long term use of these medications.
OLD TREATMENT: The best treatment for too much acid (hyperchlorhydria) is sodium bicarbonate; i.e., Alka-Seltzer. More than one package may be necessary taken in the 15 to 30 minutes after a meal and before bedtime.
Our case reports confirm that the increased incidence of hypertension in the darker races correlate with very low levels of vitamin D. After treatment with 10,000 iu of vitmain D3 drops in the mouth nightly, gingko biloba 120mg four times per day can be very helpful. Now, with the availability of sildenafil 20mg(Viagra®) for pulmonary hypertension, this medication can be take nightly and, together, may significantly lower mild-moderate blood pressure. Of course diet, exercise, quit smoking and good sleep are of primary importance.
H: HYPOACTIVE SEXUAL DESIRE DISORDER (HSDD)
Hypoactive Sexual Desire Disorder was termed 'frigidity' not too many years ago. Recent research shows that a woman's ability to orgasm depend on her brain's release of oxytocin. Environmental toxins called xenoestrogens interfere with normal brain production of natural estrogens and testosterone These toxins also create a barrier for normal oxytocin release. Man-made chemicals such as Vyleesi® and Addyi® do not correct either the xenoestrogen or the brain'S Hypothalamic-Pituitary-Gonadal axis dysregulation. Sex Hormone Bindng Globulin (SHBG) is a factor newly recognized and a major focus of the Editor.
NEW RESEARCH: The Editor hypothesizes that the neuron link between the clitoris nipples and the amygdala is testosterone. Application of low dose testosterone to the clitoris induces engorgement and (if not painful) desire for intercourse. The author has found a non-testosterone that is more effective: the women call it 'Honeymoon cream.' An IRB is panned to evaluate this and alternativ delivery systems to nasal for oytocin in the treatment of HSDD. Antidepresants (both SSRI and NSRI) inhibit oxytocin release as do man-made synthetic hormone contraceptive (oral, transdermal, IUD and subcutaneous implants).
NEW TREATMENTS: Contact usdoctor.online for information about the research with
* mixed androgenic-anabolic steroids in women with HSDD,
* topical cream that increases oxytocin release at orgasm by 50 to 60%, and
* unique oxytocin delivery systems proven superior to nasal.
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Recent research has identified that our exposure (96% of the population) to environmental toxins (called Endocrine Disrupting Chemicals/ EDCs) such as percolates, plastics and phthalates will artificially lower TSH and raise T4 to normal range. Experimentally, the basal metabolic rate is affected by these toxins making the accuracy of standard measurements for the first time, in question.
The ability to become aroused and maintain an erection starts with adequate levels of 'free' testosterone in the male. Obesity and low testosterone predict erectile dysfunction. High levels of estradioland SHBG are associated with poorer sexual function. The use of PGE synthetase inhibitors (like Viagra®/sildenafil)can improve sexual function, but not arousal. The generic sildenafil 20mg(Revatio®) costs less than $1.00 each. When crushed and absorbed under the tongue, it works as well as 100mg of Viagra®.
WOMEN can use the sublingual sildenafil (as Berman/Berman gave women 50mg of Viagra®/sildenafil). But, again, women need adequate levels of free testosterone as well.
Although Abilify seems to be the choice of general practitioners for A.D.H.D. children, the missed underlying diagnosis may well be personality disorder.Seroquel®/quetiapine "may be efficacious in the treatment" and be ten times less expensive.
Insomnia is a disorder than affects more than 60% of men and women over age 50 years. Over-the-counter treatments include Nyquil PM, melatonin, GABA and benadryl. Commonly prescribed medications such as Lunesta®/eszopiclone, Ambien®/zolpidem and benzodiazepine (Xanax®/alprazolam) interfere with normal stage 4 and REM sleep. The best prescription medication for normal sleep in gabapentin, but after 4 days many develop tolerance. A medication often used off-label that does not suppress REM sleep is Desyrel®/trazadone in doses of 25mg (1/2 tablet) or less. Seroquel®/quetiapine fumarate (25mg or less) Despite Seroquel®/ quetiapine's sedative properties, current data do not appear to support its use as first-line treatment for sleep complications. Restoril®/temazepam act negatively, like benzodiazepines on sleep. These prescription medications need the decision making process of your healthcare professional.
Restasis®/ cyclosporine is prescribed for 'dry eyes'. It is a chemotherapy agent causing tearing which treats the symptoms. A treatment/cure may be short term use of nandrolone in hyperosmolar or buffered eye drops given locally two to three times per day". The effect of the anabolic steroid to 'heal' the cornea is noted in the Case Report.
Lactation difficulties have been thought to be psychological but new research/patent may point to a hormonal deficiency of pituitary release of oxytocin. A new product/ stanozolol cream, is hypothesized to increase stimulation from the nipple to the spinothalamic reflex center resulting in increased oxytocin release and improved milk letdown. No changes are noted in the mother's serUM when the cream is applied for 5 minutes and washed off. One study with domperidone showed modest increase in milk production, but the F.D.A. has issued warning not to use this medication, noting increased sudden cardiac death and ventricular arrhythmia in mothers and high sodium levels in the neonates.
L: LIVER CANCER Liver cancer is the third most common cancer after lung and breast. It is Gender-Specific as more women are affected. New research has noted that the cancer is promoted by estrogens and specifically by the proliferation of the Estrogen Receptor-alpha.
NEW LINE OF RESEARCH:
Lung cancer is one of the most common cancers. Studies have shown the connection to smoking, an environmental toxin. Present treatment is excision, chemotherapy and biologics. More women die with lung cancer than breast cancer.
NEW DIAGNOSTIC TESTING: It is known that non-small cell lung cancer is promoted by increased levels of Estrogen Receptor-beta.
NEW RESEARCH: Performing the protocol of the Bio-Fit laboratory will support the finding of elevated Estrogen Receptor-beta versus ER-alpha No one has run this test to evaluate the effect that the biologics and mixed-AAS have on the aliquots. Should either or a combination of drugs lower the ER-beta toward normal and normalize the cytokines, the effect on the course of disease should be observed and fully evaluated. Repeat of the initial protocol will hopefully offer new information and maybe a new direction in treatment.
Hormonal derangement is consistently noted in lupus erythematosus. there was evidence that DHEA had a modest, but clinically significant impact on health related quality of life in the short term. McGuire also noted the modest benefits of DHEA but, added that danazol also may be helpful and estrogens are to be avoided.
The data with anabolic steroids is mixed. The animal model did well but the only one reference reported that women tolerated the therapy for up to 16 months. Our case report responded well to testosterone and nandrolone and stanozolol; then we reduce her to bimonthly injections of testosterone and stanozolol alone.
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M:MEDICARE FOR ALL: FALLACIES
SUMMARY: FACTS
1. Medicare will be bankrupt by 2026 as costs exceed contributions from the younger population of workers.
2. Both the older and younger members of the US are 'sicker' and consuming more financial costs for health care.
3. Government rules and regulations hinder the population from buying more cost-effective and identical medications from Canada and Europe.
4. Government rules and regulations interfere with disease modifications that are not sponsored by the pharmaceutical companies.
5. Compounded medications are less expensive. Under 'The Right to Try' laws, these should be available and covered by insurance programs when they prove effective.
6. Pharmacy Benefit Managers should be eliminated due to abuse of the system.
NEW PROGRAM:
1. COST of DRUG TRANSPARENCY. The Editor offers an APP that compares all drugs in the US and Canada for the Best pricing. Called: RightDrugRightPrice.com . The program eliminates the $600 billion annually as the PBM "cut of the pill profits." Prior Authorization are a part of a city government plan; it can eliminate most out-of-pocket drug deductibles.
2. PREVENTIVE CARE. Utilizing the City Health Fair, the individual medical records, laboratory blood and EKG, pulmonary function, and testing is consolidated for the patients: for the cloud, the patients phone, PC and a strap-on usb chip.
3. LABORATORY SCREENING. New data is emerging that routine screening of bioavailable testosterone (total testosterone and SHBG) are biomarkers of extent of disease.
The Bio-Fit® laboratory can test various drugs in test tubes to determine the best auto-immune hormonal drug therapy.
4. Elimination of insurance company's non-payment for medications that work.
Insurance companies have no right to prescribe medications; that is the role of the physicians. If their are restrictions on procedures such as late-trimester abortion or testosterone injections, should be only in contract from the insurer company and the individual. There should not be any limit on compounding pharmacies that are licensed by each state. There should be no restriction on non-pharmaceutical supported research, Canadian prescriptions and supplements that are effective treatment instead of prescription medications.
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Single bio-identical estradiol) is available as the Minivelle® patch, Estrace®/estradiol tablet and cream, adding natural progesterone (Prometrium®) in those women with a uterus, ERT should be an absolute for most peri- and menopausal women. As the W.H.I. showed in the second arm, the increase risk of cancer came from the progestin. In reference to increase in thrombotic phenomenon,the reader is referred to our Webpage about fibrinolysis. Stanozolol which is an androgen component of the mixed androgen injection and metformin (used to reduce carbohydrate absorption)
effectively prevent for most, any thrombotic risk.
There are others have published key medical journal articles establishing that migraine near/during the menses is CAUSED by hormonal fluctuation and most often can be prevented by keeping hormone levels stable. In general, migraine is a state of low testosterone, and low estradiol. Option One: Stable higher estradiol(estradiol patch), estradiol pellets, and weekly estradiol injections. Option Two: low estradiol levels (danazol, mixed androgenic-anabolic steroid (AAS) injection, testosterone pellets. The tension component responds to trigger point injections, topical ketoprofen-DMSO and Cyclobenzaprine (available compounding pharmacy)and for a few weeks to months, Botox®.
The new Calcitonin Gene-Related Peptides (CGRP) are extremely expensive, have a 50% or more failure rate and in the editor's opinion, not often indicated.
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. The disease affects more women than men and often is diagnosed during a woman's childbearing years. Typical clinical presentations of the disease are extensive and variable, with symptoms that include dysregulated mood, fatigue, vision problems, weakness, tremor, imbalance, abnormal sensations, bladder dysfunction, and heat sensitivity. If a woman aged 15-50 years experiences these neurologic symptoms in isolation or combination, and the symptoms are not explained by other underlying medical conditions, MS should be suspected. Multiple sclerosis can be divided into four clinical subtypes: 1) relapsing-remitting MS, 2) secondary progressive MS, 3) primary progressive MS, and 4) clinically isolated syndrome. Relapsing-remitting MS at the time of onset is the most common form and accounts for approximately 80% of all cases of MS. Relapsing-remitting MS does not affect life expectancy. However, because of the neuro-degenerative and progressive course of the disease, patients accumulate physical and cognitive disabilities over time that result in impaired ability to work, increased financial burden, and slightly increased mortality. A variety of possible risk and prognostic indicators have been identified that may predict the course of disease, particularly the extent of relapses and disability. Multiple sclerosis currently is incurable, but many disease-modifying therapies are available that can reduce the frequency of clinically evident exacerbations and accumulation of disease burden as defined by the number of lesions identified on magnetic resonance imaging. The choice of disease-modifying therapies, contraception use, and treatment of symptoms should be individualized based on age at onset and disease activity and, during pregnancy, the gestational age. Proactive management of MS across the woman's life cycle reduces morbidity, improves maternal and fetal health during pregnancy and the postpartum period, and increases quality-of life-measures for patients and their families.
NEW TREATMENT: FDA approves new oral drug to treat multiple sclerosis. The U.S. Food and Drug Administration today approved Mayzent (siponimod) tablets to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
NEW RESEARCH: Laboratory results of the immune status in men and women with MS should be reported in 2021 from the Bio-Fit laboratory. Hormonal down-regulation has been confirmed: the individual hormones and SHBG have not bee consistent. Hormonal dysregulation of the HPG has been noted; results of data collection should be available i 2021.
The patent filling describes the use of a topical agent that stimulates a spinal-thalamic excitatory response from and to the clitoris before sexual stimulating beings. Secondly, Berman and Berman describe the use of sildenafil in women to encourage arousal and lubrication. The Editor has combined 20mg of sildenafil and oxytocin in a sublingual tablet that offers both partners potentially an improved responsiveness. Most important is the systemic replacement of testosterone for the woman. If there is vaginal pain, a 3% testosterone cream with or without a topical anesthetic can be effective. |
The most recent studies suggest an association between endogenous estrogen and cartilage turnover and radiographic osteoarthritis (worsened Osteoporosis); respectively, there is correlations between serum testosterone and cartilage volume (improved Osteoporosis). Testosterone replacement has been shown to prevent, slow and reverse to some extent decreased bone density. Osteoporosis should be an entirely preventable disease. Women need replacement of not only estrogen but testosterone.
Deca-Dutrabolin®/Nandrolone is associated with increase bone mineralization, diminished vertebral pain and increased mobility.
are of direct importance in the development and/or maintenance of 1) bone mineral density; and 2) testosterone and/or low levels of dihdydrotestosterone appears to be sufficient for BMD development and/or maintenance.
Ovarian Cancer is a disease that is most often well advanced before discovered. The CEA blood tests and routine ultrasound have proven to not be effective. Survival overall is approximate 50% at 5 years but, less than 30% for the most metastatic disease (Stage IV) treated with chemotherapy and radiation.
NEW RESEARCH: The term Gender-Specific Disease refers to diseases that are focused in one gender. For females that includes breast, ovarian, uterine, vaginal disease and cancer. Interestingly, the Estrogen Receptor-beta is elevated in these disease states, but, suppressed in diseases that affect both men and women such as Crohn's Disease. This has been confirmed by our studies in our Bio-Fit laboratory.
NEW TREATMENTS?: After the untreated patients with ovarian cancer undergo the Bio-Fit initial protocol they are processed with both the 'biologic' FDA approved medications and the anabolic steroids added to their individual alliquots. Should the cell cultures show normalization of the Estrogen Receptors and the cytokines, that medication or medications are term 'best fit'. The treating physician and the patient my elect to treat accordingly. Follow up of the initial protocol is compared to the state after de novo treatment. Analysis could show no effect, or positive or negative effect on the intercelluar ERs and cytokines. These will be compared the clinical outcome.
While PreMenstrual Syndrome (PMS) and (PMDD) are classified by the DMS-V as psychiatric diseases,
Deeny's matched control studies shows an overwhelming response of patients' symptoms to low dose danazol/ hormonal therapy. It is logical that if the PMS/ PMDD symptoms respond to hormonal manipulation, then the disease's origin is hormonal. Most gynecologists are familiar with low dose danazol 200-300mg daily for 25 days per month. The Editor prefers to advise the women that this is a hormonal derangement, not a psychological manifestation, based on response to treatment with danazol.
Estrogen Receptor-alpha promotes prostate cancer and progression.
NEW DIAGNOSTIC TESTING:
POTENTIAL RESEARCH:
Oxandrolone is an effective adjunct to facilitate weight restoration in patients with COPD-associated weight loss. Weight gain is primarily lean body mass. Oxandrolone was relatively well tolerated and, therefore, should be a consideration in the comprehensive management of patients with COPD and weight loss.
For those with asthma and moderate disease, refer to the article by Schrader utilizing IV ascorbic acid and magnesium. Nebulizers of DHEA-s is an innocuous at home treatment.
Numerous studies speak to the improvement of Quality of Life with replacement of the bio-identical hormones. Specific mention is made of thyroid and sex hormones that include testosterone for men and estradiol for women. However, DHEA and other anabolics (testosterone and nandrolone for women as well as men) and Anavar®/oxandrin improve multiple aspects of healing.
More than 1.5 million Americans have Rheumatoid Arthritis. In the U.S. $4.6 billion is spent on Humira®/ adalimumab alone for Rheumatoid Arthritis. Cochrane Review of stnadard therapy . A combination of anabolic steroids could reduce the need for Humira®, methotrexate and other rheumatoid arthritis medications by 50% yielding savings of $2.5 billion while improving qualify of life.
. SHBG is being recognized as a biomarker of various disease states. Liver production of SHBG increases when exposed to female hormones and alcohol.
The Editor reports on two cases of women with seizures around their menses. Neither had endometriosis and both that were successfully treated with 1)danazol alone, and 2)danazol and anti-epileptic medications. There was no evidence of cerebral endometriosis.
Herzog reported [in reference to seizures] "Successful open label trials using cyclic natural progesterone supplement, depomedroxyprogesterone and gonadotropin-releasing hormone analogues in women and using testosterone with or without aromatase inhibitor in men have been reported."
T: TRAUMATIC BRAIN SYNDROME (TBI)
Vaginitis health costs are estimated at $500 million per year. There are more than 7.4 million new trichomonas infections each year. Treatment is broken down into three steps: (1)Self-treatments for recurrent vulvo-vaginal candidiasis (yeast) include Gentian Violet 1% applied to the upper third on a tampon or over-the-counter Monistat®. Step (2) includes prescription Metronidazole for trichomonas. Step (3) includes a pelvic examination by a health professional with PAP Smear and DNA testing to detect gonorrhea, HPV, chlamydia. Vaginal cultures are added for unresponsive cases.
DE Vaughan states that "thrombolytic agents (streptokinase, alteplase, Abciximab, urokinase) are proven to be efficacious in the treatment of acute thrombotic events..but.. they are not a viable option for long-term administration. There are numerous drugs available that indirectly increase fibrinolytic activity by reducing plasma levels of plasminogen activator inhibitor-1 (PAI-1), including ACE inhibitors, insulin-sensitizing agents, and hormone replacement therapy ((danazol, stanozolol) in women. At present, efforts are underway to develop and test synthetic, selective PAI-1 antagonists. The potential applications of PAI-inhibitors to thrombotic disorders (arterial and venous), amyloidosis, obesity, polycystic ovarian syndrome, and perhaps even type 2 diabetes mellitus. However, use in cardiovascular disease has yielded disappointing results. The addition of metformin [Editor: to an androgen such as stanozolol improved fibrinolytic activity by lowering PAI-1] and may be a subject of future study as well as compassionate use."
V: VIRAL INFECTIONS, HEPATITIS A, B, C
The Japanese suffered with contaminated blood products after World War II and developed a massive outbreak of viral hepatitis. They discovered that Glycyrrhiza Glabra, used as an intravenous therapy of 80-120mg multiple times per week offered some respite and some cures from both Hepatitis B and Hepatitis C. Flore reported that "Historical sources for the use of Glycyrrhiza species include ancient manuscripts from India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus-induced cirrhosis the risk of hepatocellular carcinoma was reduced....In vitro studies reveal antiviral activity agsints HIV-1, SARS, and other viral infections." The Editor has. used this to lower abnormal hepatitic markers (ALT, AST, GGT) even when the cause was not identified.
Other reports include use of glycyrrhizin for recurrence of hepatitis B and glycyrrhiza's role as an interferon stimulator.
Although not typically thought as useful for weight loss, there is a definite role that Androgens Play in Weight Loss by building muscle and burning off fat. All the hormones including thyroid, adrenal, vitamin D and good sleep(growth hormone) play important roles. The off-label use of Victoza® (only approved for diabetes) caused patients to comment that the side-effects of severe headaches and some GI distress were distressing. It killed the appetite for days resulting in a pound weight loss in one week. Discuss side-effects with your physician.
Anavar®/Oxandrin improves long-term recovery of severely burned children.
