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LABS- ANALYSIS of H.I.S. and H.E.R. Panels

Observation: These panels have been used as part of the initial evaluation of our patients for more than 25 years so they can "Take Control of their Health."
The H.I.S. and H.E.R. panel test almost 100 blood parameters circulating in the blood.

CBC: The Complete Blood Count evaluates the three components of blood: white cells, red cells and platelets. The white blood cells assess immune function, bacterial and viral exposure. The red blood cells detect anemia and often directs to its cause. The platelets are necessary for normal clot formation; highs or lows are found in specific states of disease.
Referenced Articles Laboratory Test Patient Value Normal Range
Complete Blood count
Overview of White Blood Cells White Blood Count 3.8-5.10 million/uL
Anemia of Red Blood Count 3.8-5.10 million/uL
Chronic Inflammation Hemoglobin 11.7-15.5 g/dL
Hematocrit 35.0- 45%
Platelet Dysfunction Platelet Count 140-400 Thousand/uL

The Metabolic Panel measures 18 markers of liver, kidney function, electrolytes and magnesium. When out-of-balance, those taking prescription medication may need to supplement iron, calcium, sodium, potassium and/or magnesium. For example, low potassium from blood pressure medications can lead to cardiac arrhythymia, high calcium is a sign of osteoporosis, and low magnesium may be signs of excessive alcohol ingestion.

Laboratory Test Patient Value Normal Range
Metabolic Panel
Glucose 65-99 mg/dL
Overview Kidney Disease BUN/ Urea Nitrogen 7-25 mg/dl
eGFR/ non-Afr. American greater than 60 mL/min/1.73m2
Overview Kidney Disease (eGFR) eGFR/ Afr. American greater than 60 mL/min/1.73m2
BUN/Creatinine Ratio 6-22 calculated
Overview of Sodium Sodium 135- 146 mmol/L
Overview Potassium Potassium 2.5- 5.3 mmol/L
Overview Potassium Chloride 98-110 mmol/L
Overview Acid-Base Balance Carbon Dioxide 19-30 mmol/L
Overview Calcium Calcium 8.6 - 10.4 mg/dL
Protein 6/1- 8.1 g/dL/L
Albumin 3.6 -5.1 g/dL
Globulin 1.9 - 3.7 g/dL
Albumin/ Globulin Ratio 1.0 - 2.5 calculated
Bilirubin, total 0.2 to 1.2 mg/dL
Alkaline Phosphatase 33- 130 U/L
AST 10- 35 U/L
ALT 6- 29 U/L
Magnesium 4.0-6.4 mg/dl

Diabetes, Glucose Metabolism, Overweight and 'Sugar" Metabolic Abnormalities are under the influence of insulin. Healthy fasting insulin is less than 2; early stage diabetics on no medication may have fasting insulin of not just 12 but 25+! Although the laboratory may measure fasting insulin, a simpler test is to measure the 3-month average of glucose in the blood stream. This is called the Hemoglobin A1c (HgB A1c). This show much glucose has been stored in every cell in the body over the past 3 months: too much glucose clogs the system and creates obesity. Being obese, having an elevated HgbA1c, in combination with other abnormal hormone levels predict the development of diabetes, obesity and metabolic diseases, but it is one of the key measurements that predict premature aging, heart disease and risk for cancer.

To confirm the diagnosis of diabetes, the American Diabetic Association requires a 2(two) Glucose Tolerance Test (GTT). Before drinking a GLucosa (sugar drink) with 50 grams of glucose, the fasting blood glucose should be under 100mg/dL; the 1 hour under 145 mg/dL and the 2-hour under 125 ng/dl. Two elevated values are diagnostic of diabetes.

However, Kraft in 3,650 insulin glucose tolerance tests found that 2/3rds of "normal" GTT had abnormal insulin tests. As these patients were referred to rule out diabetes, he established that many metabolic abnormalities were missed by the standard 2-hr GTT.

The Insulin-Glucose Tolerance Test is performed the same as the GTT with the addition of insulin and glucose blood levels at start, 1/2hour, 1-hour, 2-hour and 3-hour.Kraft [Detection of Diabetes Mellitus, In Situ (occult diabetes), Kraft, Joseph R., Laboratory Medicine, Volume VI, #2, pages 10-22, February 1975] determined four abnormal insulin patterns:

*Pattern 1: Normal is defined as fasting insulin under 30 units (we consider 12 upper limits); peak insulin at 1/2 to 1 hour. The summary of the second and third insulin must be less than 60.
*Pattern 2: Normal fasting. Peak at 1/2 to 1 hour with delayed return of insulin to baseline. Measurement of second and third hour insulin between 60-100 considered borderline for diabetes. Greater than 100 considered diabetes.
*Pattern 3:Normal fasting insulin. Peak insulin at second or third hour. This Kraft considers diagnostic of diabetes.
*Pattern 4: Fasting insulin greater than 30. Kraft felt this was diagnostic of diabetes.
*Pattern 5: No insulin level greater than 30. Kraft felt this was diagnostic of a juvenile pattern (inadequate insulin production). [Editor] this is also present in 'burned out' adult diabetes. These individuals almost always require insulin.

Category of Testing Laboratory Test Patient Value Normal Range
Hemoglobin A1c less than 5.7% of total hemoglobin 2- 10
Fasting Insulin Level 2- 12
Glucose Levels 65-99 mg/dL 110-125 mg/dl is "impaired fasting glycemia"greater than 126 mg/dL is diagnostic of diabetes
2-hr Glucose Tolerance Test with 75gm Glucola maximum 140mg/dL Glucose at 1 hour 140- 200mg/dl is "impaired glucose tolerance"greater than 200 mg/dL is diagnostic of diabetes
3-hr Glucose and Insulin Tolerance with Glucola maximum insulin level at baseline < 30 uiU/mL Peak at 1 hour sum of 2nd and 3rd hr greater than 100 uiU/L is diagnostic of diabetes.[Normal < 60uiU/L]

Thyroid: Thyroid hormone is one of the primary sources of energy. Low thyroid is associated with fatigue, obesity, cold hands, constipation and elevated cholesterol. Two-thirds of those living in the middle of the United States are hypo- (low) in thyroid. And the problem is getting worse.

The primary thryoid test is the (TSH) thyroid stimulating hormone. Normal values have dropped to less than 5 and for many physicians, less than 2. Six other thyroid tests are available: T4 free (the storage form), T3 free (the active form), Reverse T3 (misdirected making wrong thyroid), and thyroid antibodies and thyroid peroxidase antibodies. Antibodies are present in Hashimoto's thyroitis (where the body's cells attack his or her own thyroid.

Treatment is replacement of T4 (levothyroxine) and/or Natur-Throid (a mixture of T4 and T3). For some additional T3 is prescribed. This is usually compounded as the dose of Cytomel is usually too much for most individuals to take without having heart palpitations. Cytomel also has an very short half-life.

Laboratory Test Patient Value Normal Range
Thyroid Profiles
Thyroid Stimulating Hormone 0.4-4.5 mIU/mL
T4 free 0.8- 1.8 ng/dlL
T3 free 2.3- 4.2 pg/mL
Reverse T3 38- 25 ng/ dL
Thyroid Antibodies less than 20 IU/mL
Thyroid Peroxidase Antibodies less than 35 IU/mL

Cholesterol measurements are performed, yet they are less predictive of plaque in the coronary arteries than the simple 30-seond C.T. Scan of the chest called the Coronary Artery Calcium Score. Because the C.A.C.S. shows the locations of the plaque and potentially the degree of blockage, this is more predictive of heart attacks; even better than the EKG stress and echocardiogram testing. Similarly, heart attacks in men occur when he has lower testosterone, higher estrogens, lower DHEA. Other parameters that are predictive are low vitamin D levels and a drop in the testosterone/ SHBG ratio. The American Medical Association recommends that only the cheapest statin be prescribed for those found to have cardiac risk.-Many doctors urge those on statins to take quality Co-enzyme Q10 as the statins cause depletion of Co Enzyme Q-10.

Laboratory Test Patient Value Normal Range Normal Range Female Normal Range Male
Lipid Profile
Total Cholesterol 125-200 ng/dLGreater than 200 considered at risk
LDL- Cholesterol <130 mg/dl Greater than 100 considered at risk
HDL-Cholesterol Greater than 46mg/dl considered ideal Men on testosterone will be lower
Total Cholesterol/ HDL Ratio less than 5.0
Triglycerides/ HDL Ratio greater than 3.0
Triglycerides Less than 150mg/dl Should be less than 100mg/dl
Triglycerides/HDL ratios Greater than 3
Homocysteine G<10.4 umol/L Ideal less than 7umol/L

Hormones of Youth: Youthful levels of all these hormones predict an active and health-filled lifestyle even into the older years. Few realize that Vitamin D3 is a hormone that is necessary for almost 400 metabolic processes. While only 15% of Americans have normal levels, almost no African-Americans or Middle East families have adequate Vitamin D3.
Inadequate Vitamin D3 and poor REM sleep, cause a steep drop in human Growth Hormone measured as IGF-1 (Insulin Like Growth Factor-1). Sleep is disrupted by inadequate levels of testosterone in men and estrogen (estradiol) and testosterone in women.

The Adrenal gland is the source of energy. It gives you the get-up and go in the morning and prevents the 2-4 PM lull in work energy. DHEA and morning cortisol is high when young and drops in half by 50 and lower yet at 60 plus. Cortisol can be high and out of phase during bouts of depression. Pregnenolone is the 'mother' pre-hormone to DHEA and feeds every cell in the body. DHEA, pregnenolone and Vitamin D3 are three inexpensive 'energy' replacement products available over-the-counter.

Laboratory Test Patient Value Normal Range Normal Range Female Normal Range Male
Brain Hormones
Vitamin D3 25-OH 30-100 ng/ml
(IGF-1) Insulin Like Growth Factor-1 50-317ng/mL Female >160ng/ml; Male >200ng/ml
Laboratory Test Patient Value Normal Range Normal Range Female Normal Range Male
Adrenal Hormones
DHEA-s 15-170 mcg/dL Greater than 100 mcg/ml Female Greater than 150 mcg/ml Male
Cortisol AM 4- 22 mcg/dL Ideal >25 mcg/dL
Cortisol PM 4-10 mcg/dL less than 10 mcg/dL
pregnenolone ??
Sex Hormones
Total Testosterone 2-950ng/dl 2-45 ng/dL Female 300-750 ng/dL Male
Total Estradiol 19-357 pg/mL 50-350pg/ml pre-menopausal Female less than 20pg/ml normal Male
Progesterone day 23 10-19 pg/mL Ovulating Female
Sex Hormone Binding Globulin 5-300 nmol/L 20-45 nmol/L Normal Female 5-20 nmol/L Normal Male
Free Androgen Index (F.A.I.) .2-2.5 .004-.1 Normal Female .5- 2.5 Normal Male

H.I.S. and H.E.R. hormones are the primary focus of Health, Wellness and 'Aging Well'. While a man's testosterone level drops 1.5% per year, it may drop faster with illness, obesity and disease. Elevated estrogen levels in a man are associated with obesity and are found in those who suffer a heart attack. Adequate available 'to-be'used' testosterone is key to a man staying youthful and healthy: bulidng muscle, being happy, having energy and sexual function. The PSA is a marker for prostate cancer. Men with PSA greater than 3 and low testosterone are at a 33% risk for developing prostate cancer.

A woman needs both estrogen (estradiol) and testosterone. Progesterone is produced in the second half of her cycle to shed the uterine lining. Women on birth control pills, patches or rings, or being 40+ years of age or having a hysterectomy or ovary removal, will experience an 80% drop in her testosterone. At the same time, their estrogen levels drop 90%! That is why these women lose bone and muscle tone, energy, mental focus, and sexual drive.
Sex Hormone Binding Globulin (SHBG) has been the focus of study of the Editor for 25 years. It is now linked to exposure to xeno-estrogens (environmental toxins). Toxins poison the liver into making more SHBG; more SHBG corrals and neutralizes testosterone and natural estrogen. It makes women fat, 'girly' men while prematurely aging men and women. High levels of SHBG are linked in men with diabetes, heart disease, obesity, hypertension, ulcerative colitis, and death. High levels of SHBG are linked in women to endometriosis, osteoporosis, rheumatoid arthritis, Alzheimer's disease, an inability to gain muscle and lack of sexual desire, arousal, orgasm and vginal dryness/ pain.

Other Testing Reports are Available:
Iron Stores: Total iron, iron binding capacity, iron saturation index, ferritin.
Inflammation: Sedimentation Rate, C-Reactive Protein, ANA, ACE, ASO, LE factor and specific interleukin 6 and 10.
Hepatitis Screen: Hepatitis A, Hepatitis B core, Hepatitis B surface antigen, Hepatitis C.

The best predictor of True Age(R) are youthful levels of hormones. We have trained thousands of physician with programs based on the thousands of pages of medical information here at www.iDOCTOR.US. The inforation is intended to assist each one of you in your quest for "Health and Wellness." The Editor

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