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Dx Stomach Cancer: Gastro-Intestinal Stromal Tumor Treatment:

Stomach Cancer: Gastro-Intestinal Stromal Tumor

The Merck Manual Home Edition
"A Helicobacter pylori infection seems to be the cause of most stomach cancer.Vague abdominal discomfort, weight loss, and weakness are some typical symptoms.The best diagnostic procedure is an endoscopy. The survival rate is low because the cancer tends to spread early to other sites.

Surgery is performed to eliminate the cancer or relieve symptoms. About 95% of stomach cancers are adenocarcinomas. Adenocarcinomas of the stomach originate from the glandular cells of the stomach lining.

In the United States, adenocarcinoma of the stomach occurs in about 21,000 people each year and causes almost 11,000 deaths per year. It is more common among certain populations: people aged 50 and older, blacks, Hispanics, and American Indians. For unknown reasons, adenocarcinoma of the stomach is becoming less common in the United States. Worldwide, stomach cancer is the second most common cancer. It is far more common in Japan, China, Chile, and Iceland. In these nations, screening programs are an important means of early detection.

Causes and Risk Factors
Adenocarcinoma of the stomach often begins at a site where the stomach lining is inflamed. Infection with the bacterium Helicobacter pylori is the cause of most stomach cancer. People who have certain gene mutations are also at risk.

Stomach polyps may become cancerous (malignant) and are thus removed. Adenocarcinoma of the stomach is particularly likely to develop if the polyps consist of glandular cells, if the polyps are larger than ¾ inch (2 centimeters), or if several polyps exist.

Certain dietary factors were once thought to play a role in the development of adenocarcinoma of the stomach. These factors included a high intake of salt, a high intake of carbohydrates, a high intake of preservatives called nitrates (often present in smoked foods), and a low intake of fruit and green leafy vegetables. However, none of these factors has proved to be a cause."

Medications Used in Treatment:
1. Antimetabolites: 5-Flurouracil
2. Surgery: most cancers remain inoperable

Suggested Links:
*N.H.S. Choices
*Gastric Cancer Foundation

[Editor] More than 70 years ago, John A. Myers, M.D. documented that the mortality rates from stomach cancer in Wales directly correlated with the areas with the high organic matter (high population concentrations) and trace mineral deficiencies (copper, zinc, manganese, vanadium, selenium, iodine) [Metabolic Aspects of Health, 1979]. A recent Chinese study showed that 2 weeks of antibiotics for Helicobacter pylori reduced the prevalence of precancerous gastric lesions while vitamins and selenium did not. In the Library of the National Institute of Health (, there are numerous articles that link low levels of selenium, vanadium, manganese and vitamins to increased incidence of cancer. The Japanese National Cancer Institute 2010 stated:The beneficial effects of selenium, vitamin E, and beta-carotene on mortality were still evident up to 10 years after the cessation of supplementation and were consistently greater in younger participants. Late effects of other supplementation regimens were also observed.

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