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Dx Human Immunodeficiency Virus (Dx H.I.V.) (Dx A.I.D.s.) Treatment: Read more...


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Observation:
Treatment of H.I.V./A.I.D.s

Pubmed.org
states:
"Nevertheless, anabolic-androgenic steroid hormones appear to have legitimate uses in certain patients. In HIV-infected, hypogonadal men, anabolic steroid hormones optimize muscle strength and muscle mass when combined with resistance exercise. Although a large number of people have used these drugs for many years, no studies of the long-term health effects have been done. However, when taken in supraphysiologic doses, these drugs are known to cause a wide range of acute adverse effects. When used in less then supraphysiologic doses in eugonadal or hypogonadal HIV-infected patients, these drugs reverse HIV-related hypogonadism, muscle wasting, and perhaps lipodystrophy. Provided that the oral preparations are not used and patients are closely monitored, anabolic-androgenic steroid hormones,nanrolone more so that testosterone offer HIV-infected patients a better quality of life and an improved sense of well-being."

Medications Used in Treatment:
1. HIV NRTIs: Truvada®/embtitabine-tenofovir-pmpa,Videx®/didanosine, Retrovir®/zidovudine-ZDV, Trizivir®/abacavir-lamivudine-3TC-zidovudine-ZDV, Viread®/tenofovir, Epzicomv/abacavir-lamivudine-3TC, Epivir®/ lamivudine, Ziagen®/abacavir, Emtrivav/rmtricitabine, Zeritv/stavudine
2. HIV Protease Inhibitors: Crixivan®/indinavir, Aptivus®/ tipranavir, Atripla®/efavirenz-emtricitabine-tenofovir, Prezista®/darunavir, Reyataz®/atazanavir, Kaletra®/lopinavir, -ritonavir, Combivir®/lamivudeine-zidovudine, Lexiva®/fosamprenavir, Vircept®/nelfinavir, Invirasev/saquinavir
3. HIV NRTI/NNRTI combinations: Complera®/ emtricitabine-rilpivirine-tenofovir
4. hGH:Omnitrope®
5. Anabolic steroids: Oxandrin®

*Medscape
*Elton John AIDS Foundation


*[Editor] Almost 20 years ago the "Safety of high dose of rhGH was published with a subsequent article by Krentz stating "Recombinant human growth hormone (r-hGH) is given as substitution therapy to growth hormone-deficient children at 0.01-0.025 mg/kg/day. Higher doses are used for short stature due to Turner's syndrome and for idiopathic short stature (approximately 0.05 mg/kg/day). For metabolic indications such as AIDS-associated wasting and severe burns, even higher doses are required, up to 0.2 mg/kg/day. Worldwide experience with low and medium doses of r-hGH is well documented. Data on long-term treatment with pharmacological doses of r-hGH are scarce. Serono's clinical program for AIDS-associated wasting provides placebo-controlled data on 355 treated patients. The total experience in clinical trials covers more than 100 person-years of treatment on approximately 600 patients. The most common side effects were tissue turgor complex and musculoskeletal discomfort. Leukopenia was found more frequently in placebo patients. Neoplasm, hyperglycemia, hypertriglyceridemia, carpal tunnel syndrome, pseudotumor cerebri and hypercalcemia were not found to be more significant than with substitution therapy."

*[Editor] Equally or more important has been the use of nandrolone for these patients. The trials showed the nandrolone group recorded maximum mean increase in weight (3.2kg), increase in body mass index more than testosterone and a better quality of life." The same was reported by J Gold. Watson stopped making nandrolone in the U.S. to sell Oxandrin which is less potent and ten to twenty times as expensive.HIV advocates express strong concern but are rebuffed by politicians and Washington.

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