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Dx Colon Cancer Treatments:

Colon Cancer

The Merck Manual Home Edition
"Almost all cancers of the large intestine and rectum (colorectal) are adenocarcinomas, which develop from the lining of the large intestine (colon) and rectum. Colorectal cancer usually begins as a buttonlike swelling on the surface of the intestinal or rectal lining or on a polyp. As the cancer grows, it begins to invade the wall of the intestine or rectum. Nearby lymph nodes also may be invaded. Because blood from the wall of the intestine and much of the rectum is carried to the liver, colorectal cancer usually spreads (metastasizes) to the liver soon after spreading to nearby lymph nodes. In Western countries, cancer of the large intestine and rectum is one of the most common types of cancer and the second leading cause of cancer death. The incidence of colorectal cancer begins to rise at age 40 and peaks between the ages of 60 and 75. Each year, about 143,000 people in the United States develop colorectal cancer and about 51,000 die. Coloncancer is more common among women, and rectal cancer is more common among men. About 5% of people with coloncancer or rectal cancer have cancer in two or more sites in the colon and rectum that do not seem to simply have spread from one site to another."

Medications Used in Treatment:
1. Folate Analogues: Leukovorin
2. Nucleoside Metabolic Inhibitors: Adrucil
3. Kinase Inhibitors: Gleevec
4. EGFR Inhibitors: Erbitux
5. VEGF: Cometriq
6. Platinum-based Drugs: carboplatin

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*N.H.S. Choice

*[Editor] The New York Times article of April 2014 reported from the science magazine's article that taking aspirin regularly (at least 2 times per week) reduced the risk of colon cancer by 50% in individuals with high levels of 15-PGDH enzymes in the gut. The author suggested that this enzyme can be measured by taking an extra biopsy during a colonoscopy, therby determining which individuals should take aspirin.

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