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Dx Immunodeficiency Treatments:

Primary immunodeficiency

Mayo Clinic
By Mayo Clinic Staff
Primary immunodeficiency disorders — also called primary immune disorders or primary immunodeficiency — weaken the immune system, allowing repeated infections and other health problems to occur more easily. Many people with primary immunodeficiency are born missing some of the body's immune defenses, which leaves them more susceptible to germs that can cause infections. Some forms of primary immunodeficiency are so mild they may go unnoticed for years. Other types of primary immunodeficiency are severe enough that they are discovered almost as soon as an affected baby is born. Treatments can boost the immune system for many types of primary immunodeficiency disorders. Most people with primary immunodeficiency disorders lead relatively normal, productive lives. Children are able to attend school and play with friends."

"Rho(D) immune globulin is used to treat immune thrombocytopenic purpura (ITP) in patients with Rh-positive blood. ITP is a type of blood disorder where the person has a very low number of platelets. Platelets help to clot the blood. Rho(D) immune globulin is also used to prevent antibodies from forming after a person with Rh-negative blood receives a transfusion with Rh-positive blood, or during pregnancy when a mother has Rh-negative blood and the baby is Rh-positive. It belongs to a group of medicines called immunizing agents. Rho(D) immune globulin works to boost the immune system and prevent excessive bleeding.

The Rh factor is one part of the red blood cell. A person has either Rh-positive or Rh-negative blood. If you receive the opposite type of blood, your body will create antibodies that can destroy the red blood cells. When a pregnant woman is Rh-negative and her baby is Rh-positive, the baby's blood can get into her system and cause her to make antibodies. When the same woman has a second baby with Rh-positive blood, the antibodies will destroy the red blood cells in the baby. Rho(D) immune globulin is given to these women during pregnancy or after delivery to prevent them from making antibodies. This medicine is to be administered only by or under the supervision of your doctor.

This product is available in the following dosage forms:
*Powder for Solution

Medications Used in Treatment:
1. Human Immune Globulin: Hizentra®/ Rho[D] immune globulin, Winrho® RhO[D] immune globulin, Gammagard®S/D-immune globulin

Suggested Links:
*Medscape/ Common Variable Immunodeficiency
*Immune Deficiency Foundation

*[Editor] A review of the literature noted that the androgen, danazol, has been used in select cases of immunodeficiencies:
Danazol therapy for chronic immune-mediated throbocytopenic purpura in a patient with common variable immunodeficiency. 1991
Autoimmune hemolytic anemia in chronic mucocutaneous candidiasis. 1994.
Danazol is usually ineffective but, sometimes effective in HIV-related thrombocytopenia. 1989.

*[Editor] A new CLIA-waived oral fluid rapid HIV-1/2 antibody test is available for in office diagnosis in 20 minutes from OraQuick.

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