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Dx Pre-eclampsia Treatment:

Preclampsia and Eclampsia

The Merck Manual Home Edition
"Preeclampsia is high blood pressure that is accompanied by protein in the urine and that develops after the 20th week of pregnancy. Eclampsia is seizures that occur in women with preeclampsia and that have no other cause.

Preeclampsia can cause the placenta to detach and the baby to be born too early, increasing the risk that the baby will have problems soon after birth.
*The woman's hands and feet may swell, and if preeclampsia is severe and not treated, she may have seizures (eclampsia) or organ damage.
*Depending on how severe preeclampsia is, treatment may involve bed rest, hospitalization, drugs to lower blood pressure, or delivery of the baby as soon as possible.
*Magnesium sulfate is given by vein to prevent or stop seizures.

About 3 to 7% of pregnant women develop preeclampsia (toxemia of pregnancy). In preeclampsia, an increase in blood pressure is accompanied by protein in the urine (proteinuria). Without treatment, preeclampsia can suddenly cause seizures (eclampsia). Eclampsia occurs in 1 of 200 women who have preeclampsia. If not treated promptly, eclampsia is usually fatal.

Preeclampsia (with or without eclampsia) develops after the 20th week of pregnancy and usually before the end of the first week after delivery. One fourth of the cases occur after delivery, usually within the first 4 days but sometimes up to 6 weeks after delivery.

*Preeclampsia and eclampsia can develop after delivery

HELLP syndrome: This syndrome develops in 1 or 2 of 10 women with severe preeclampsia or eclampsia. The HELLP syndrome consists of the following:
*Hemolysis (the breakdown of red blood cells)
*Elevated levels of liver enzymes, indicating liver damage
*Low platelet count, making blood less able to clot and increasing the risk of bleeding during and after labor

Most pregnant women with this syndrome have high blood pressure and protein in the urine, but some have neither.

The cause of preeclampsia is unknown. But it is more common among women who
*Are pregnant for the first time
*Are carrying two or more fetuses
*Have had preeclampsia in a previous pregnancy
*Have relatives that have had preeclampsia
*Are obese
*Already have high blood pressure or a blood vessel disorder
*Have a blood clotting disorder
*Are younger than 17 or older than 35

Some women have no symptoms. In others, preeclampsia causes fluids to accumulate (edema), particularly in the hands and face and around the eyes but also in the feet. Rings may no longer fit. Women may gain excess weight.

Tiny red dots (petechiae) may appear on the skin, indicating bleeding in the skin. Women may feel jittery.

If severe, preeclampsia can damage organs, such as the brain, kidneys, lungs, heart, or liver. Then women may have headaches, distorted vision, confusion, difficulty breathing, pain in the upper right part of the abdomen (over the liver), vomiting, or other symptoms. If the HELLP syndrome develops, it may cause similar symptoms. The HELLP syndrome can develop before symptoms of preeclampsia appear. A pregnant woman who has a new headache that does not resolve with acetaminophenbor within 24 hours should call her doctor.

Preeclampsia may cause few noticeable symptoms for a while, then suddenly worsen and cause seizures (eclampsia).

Babies may be small because the placenta malfunctions or because they are born prematurely. Babies of women with preeclampsia are 4 or 5 times more likely to have problems soon after birth than babies of women who do not have this complication.

Rarely, preeclampsia may cause the placenta to detach too soon (called placental abruption (Placental Abruption).

Doctors diagnose preeclampsia when a woman has the following:
*Typical symptoms such as headache, swelling around her eyes, and particularly swelling of her hands
*Increased blood pressure during the pregnancy
*Protein in the urine

Doctors do blood and urine tests to confirm the diagnosis, to determine how severe preeclampsia is, and to check for organ damage. Doctors also check the fetus's heart rate. Ultrasonography is done to check other signs of the fetus's well-being, such as movements, breathing, and muscle tone.

Delivery is the best treatment, but doctors must weigh the risk of an early delivery against the severity of preeclampsia. Delivery is usually done as soon as possible in the following situations:
*Severe preeclampsia if the pregnancy has lasted more than 34 weeks or if fetus's lungs are mature
*Worsening organ damage in the woman
*Problems in the fetus

If delivery can be delayed in pregnancies of 32 to 34 weeks, women are given corticosteroids to help the fetus's lungs mature. If the pregnancy has lasted longer than 36 or 37 weeks and preeclampsia is mild, the baby is delivered.

Mild preeclampsia:
If mild preeclampsia develops early in the pregnancy, women are advised to modify their activities. For example, they are advised to stop working if possible, stay seated most of the day, and avoid stress. Also, these women should see their doctor 2 to 3 times a week. However, most women with mild preeclampsia are hospitalized, at least at first. There, they are kept in bed and monitored closely until the fetus is mature enough to be delivered safely. Drugs to lower blood pressure (antihypertensives) may be needed. If blood pressure and other problems can be controlled, women may be able to go home, but they must see their doctor every 2 to 3 days.

If preeclampsia develops near the due date, labor is usually induced and the baby is delivered. Magnesium sulfate is given during labor to prevent seizures.

Severe preeclampsia and eclampsia:
As soon as severe preeclampsia or eclampsia is diagnosed, women are given magnesium sulfate intravenously to prevent or stop seizures. If women have seizures after being given magnesium sulfate, an anticonvulsant (diazepam or lorazepam) is given intravenously.

The baby may be delivered by cesarean, which is the quickest way, unless the cervix is already opened (dilated) enough for a prompt vaginal delivery. A prompt delivery reduces the risk of complications for the woman and fetus. If blood pressure is high, drugs to lower blood pressure, such as hydralazine or labetalol, may be given intravenously before delivery is attempted. The HELLP syndrome is usually treated the same way.

After delivery:
After delivery, women who have had preeclampsia or eclampsia are given magnesium sulfate for 24 hours and closely monitored for 2 to 4 days because they are at increased risk of seizures. As their condition gradually improves, they are encouraged to increase their activities. They may remain in the hospital for a few days, depending on the severity of the preeclampsia and its complications.

After returning home, these women may need to take drugs to lower blood pressure. Typically, they have a checkup at least every 1 to 2 weeks for the first few months after delivery. Their blood pressure may remain high for 6 to 8 weeks. If it remains high longer, the cause may be unrelated to preeclampsia."

Medications Used in Treatment:
1. Magnesium supplements: Magnesium sulfate

Suggested Links:
*N.H.S. Choices
*Medscape/ Severe Preeclampsia/ H.E.L.L.P. Syndrome

*[Editor] The risk of the development of severe preeclampsia increases for women with high second-trimester AFP, human chorionic gonadotropin, inhibin, and/or low unconjugated estriol; this is especially true for early-onset severe preeclampsia. When abnormal biomarkers co-occur, risk dramatically increases. Although the screening value of second-trimester biomarkers is low, abnormal biomarkers, especially when occurring in combination, appear to indicate placental dysfunction that is associated with the development of severe preeclampsia.".

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