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Dx Cushing's Disease Treatments:

Cushing's Disease

Merck Manual Home Edition states:
"In Cushing syndrome, the level of corticosteroids is excessive, usually due to overproduction by the adrenal glands. Cushing syndrome usually results from a tumor in the pituitary gland that causes the adrenal glands to produce excessive corticosteroids. People with Cushing syndrome usually develop excessive fat throughout the torso and have a large, round face and thin skin. Doctors measure the level of cortisol to detect Cushing syndrome. Surgery or radiation therapy is often needed to remove a tumor. The adrenal glands may overproduce corticosteroids because of a problem in the adrenal glands or because of too much stimulation from the pituitary gland. An abnormality in the pituitary gland, such as a tumor, can cause the pituitary to produce large amounts of corticotropin, the hormone that controls the production of corticosteroids from the adrenal glands (a condition known as Cushing disease). Tumors outside the pituitary gland, such as small cell lung cancer or a carcinoid tumor in the lungs or elsewhere in the body, can produce corticotropin as well (a condition called ectopic corticotropin syndrome). Sometimes a noncancerous tumor (adenoma) develops in the adrenal glands, which causes them to overproduce corticosteroids. Adrenal adenomas are extremely common. Half of all people have them by the age of 70. Only a small fraction of adenomas produce excess hormone, however. Cancerous tumors of the adrenal glands are very rare. Cushing syndrome can also develop in people who must take large doses of corticosteroids because of a serious medical condition. Those who must take large doses have the same symptoms as those who produce too much of the hormone. The symptoms can occasionally occur even if the corticosteroids are inhaled, as for asthma, or are used topically."

Medications Used in Treatment:
1. Somatostatin Analogues:
2. Progestin Antagonists:

Suggested Links:
* N.H.S. Choice
* Medscape on Risk Factors

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