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Dx Progesterone Replacement: Read more..


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Observations:
Topical and Oral Progesterone Supplementation for P.C.O., P.M.S. and Menopause:


*[Editor]:
Blood Levels: Tissue Blood Levels do rise with Topical 8% progesterone
For more than 15 years, the observations of John Lee, M.D., that topical progesterone offered premenstrual reproductive women and menopausal women benefits have been scoffed and ignored. A most recent publication in the respected journal, Menopause confirmed that topical progesterone (80mg/day = 8%) was 100-fold greater in the capillary blood and 10-fold higher in the saliva then in the serum or whole blood. "Reliance on serum levels of progesterone ...could lead to underestimation of tissue levels..".

Topical Progesterone demonstrates 'protective' anti-proliferative effects on the endometrium
The 2005 article in the Journal Menopause stated that "antiproliferative effects on the endometrium have been demonstrated with progesterone creams when circulating levels of progesterone are low. Thus, effects of topical progesterone creams on the endometrium should not be based on serum progesterone levels, but on histologic examination of the endometrium. Despite the low serum progesterone levels achieved with the creams, salivary progesterone levels are very high, indicating that progesterone levels in serum do not necessarily reflect those in tissues."

Patients Reported Improvement: High statistical probability that the Topical Creams relieve Symptoms
A cohort study (matching similar persons into (1)treatment versus (2)no treatment) for 8 years found that Bio-identical Hormone Replacement Therapy (BHRT) whether used topically (71%) or orally (43%) resulted in:
*25% decrease in emotional lability
*25% decrease in irritability
*22% reduction in anxiety
*14% reduction in night sweats and 6% reduction in hot flashes.


*[Editor] Polycystic Ovarian Disease and Progesterone.
Per Dr. Virgina Hopkins:
I recommend supplementation of normal physiologic doses of progesterone to treat PCOS. If progesterone levels rise each month during the luteal phase of the cycle, as they are supposed to do, this maintains the normal synchronal pattern each month, and PCOS rarely, if ever, occurs. Natural progesterone should be the basis of PCOS treatment, along with attention to stress, exercise, and nutrition. If you have PCOS, you can use 15 to 20 mg of progesterone cream daily for the last two weeks of your cycle. The disappearance of facial hair and acne are usually obvious signs that hormones are becoming balanced, but to see these results, you’ll need to give the treatment at least six months, in conjunction with proper diet and exercise. If your symptoms fade, try gradually easing off the progesterone (take half the dose, for example) and see how it goes. If your symptoms return, stay on the full dose for six more months. Ideally, as a young woman you would use the progesterone cream only during the months you need it, and encourage your body to return to its own normal hormonal rhythms as much as possible. Some women with many damaged follicles may always need to supplement with a little bit of progesterone cream."

Suggested Links:
Life Extension Article explains how progesterone has a parasympathetic (calming) effect


[Editor] This confirms the fact that the topical BHRT therapies are inadequate to completely treat menopause. Only adequate blood levels of estrogen, progesterone and testosterone can suppress the pituitary hormonal level of Follicular Stimulating Hormone (FSH) and Leutinizing Hormone (LH) to pre-menopausal levels of 10-20miu/L: that is, by definition, reversal of bio-chemical menopause. See Hormone Replacement Therapy for more information.

Dermatologists report that a 2% progesterone can increase elastic skin properties, reduce wrinkles' depth and skin firmness. This occurred without any significant increase in blood levels.

*[Editor] I find the connection between the disturbances in the GI tract causing endocrine problems such as PCO most interesting. Using progesterone is practically 100% safe; a gluten and lactose free diet is not difficult. This is a simple therapy with many potential gains.

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