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Dx Alzheimer's Disease Treatment:


The consensus is that prevention is the focus as the treatments once the disease is confirmed, are dismal. Non-steroidal anti-inflammatory medications and estrogen replacement appear to decrease the relative risk of [women] developing Alzheimer Disease. Higher bio-available serum testosterone in late life predicts a lower risk of future AD in men. Furthermore, " Like estrogen, testosterone has been established as an endogenous neuroprotective factor that not only increases neuronal resilience against AD-related insults, but also reduces beta-amyloid accumulation."
Prescription medications including cholinesterase inhibitors and memantine did not improve cognition or function among patients with mild cognitive impairment and were associated with a greater risk of GI harms."
Medications used are donepezil, galantamine and rivastigmine. All are now inexpensive generic formulations; donepezil appears somewhat better in studies.

Alzheimer's Disease

The Merck Manual Home Edition
"Alzheimer disease is a progressive loss of mental function, characterized by degeneration of brain tissue, including loss of nerve cells, the accumulation of an abnormal protein called beta-amyloid, and the development of neurofibrillary tangles. Forgetting recent events is an early sign, followed by increasing confusion, impairment of other mental functions, and problems using and understanding language and doing daily tasks. Symptoms progress so that people cannot function, causing them to become totally dependent on others. Doctors base the diagnosis on symptoms and results of a physical examination, mental status tests, blood tests, and imaging tests. Treatment involves strategies to prolong functioning as long as possible and may include drugs that may slow the progression of the disease. How long people live cannot be predicted, but death occurs, on average, about 7 years after the diagnosis is made."

Medications Used in the Treatment:
1. Cholinesterase Inhibitors: Aricept®, Exelon®, Raadyne® ER
2. NDMA Receptor Antagonists: Namenda®, Namenda®XR.
3. Medical Foods: Cerefoln Nac, Axona®
4. Estrogen Hormonal therapy for Women as a preventative
5. Androgen Hormonal Therapy for Men as a preventative

National Organizations
* Alzheimer's Foundation

*[Editor]: A Formula of common antioxidants was given to 21 males and 31 females with moderate probably Alzheimer's Disease. Those who showed increase in red cell glutathione and lowered homocysteine showed significant improvement versus donepezil alone.

We [the editorial staff] agree with HW Fillit, M.D. in JAMA Internal Medicine   2002;162(17): 1934-42 who states "At present, most observational evidence, which is supported by neurobiological research findings on the action of estrogen, indicates that ERT/HRT mitigates the degeneration that may lead to AD. The lack of evidence of a role of estrogen in the treatment of AD suggests that ERT/HRT should be initiated as early as possible after menopause, before the onset or the progression of the disease. Thus, the relationship of postmenopausal hormone therapy to AD is somewhat parallel to its relationship to osteoporosis in that, in both cases, ERT/HRT seems to have a role in primary prevention."

*[Editor]: More in depth explanations about the benefits of bio-identical (natural) hormonal replacement for peri- and menopausal women can be found in the Video about The Benefits of Hormone Replacement for Women Before, During and After Menopause.

Similarly, Alzheimer's Disease seems to be preventable by the use of testosterone replacement in men. Barron states "Both estrogens and androgens exert a wide range of protective actions that improve multiple aspects of neural health, suggesting that hormone therapies have the potential to combat AD pathogenesis".

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