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Dx Atrial Fibrillation and Flutter Treatment:


With atrial fibrillation, the blood stagnates in the atrium of the heart and can form a large clot. If the clot breaks off, it can travel to the arteries of the brain and cause a stroke.

For prevention, patients with atrial fibrillation are placed first on a heart rate limiting drugs such as beta blockers and calcium channel blockers. Next, anticoagulant medications such as warfarin are added. Warfarin is inexpensive but requires weekly blood tests (INR) to finely tune the dosage of medication. Digitalis is added for heart failure.

An unrecognized, inexpensive combination of metformin and stanozolol, would probably avoid the need for weekly blood tests or anticoagulants.
Atrial Fibrillation and Atrial Flutter

The Merck Manual Home Edition
"Atrial fibrillation and atrial flutter are very fast electrical discharge patterns that make the atria contract very rapidly, with some of the electrical impulses reaching the ventricles and causing them to contract irregularly, faster, and less efficiently than normal.
*These disorders often result from conditions that cause the atria to enlarge.
*Symptoms depend on how fast the ventricles contract and may include palpitations, weakness, dizziness or light-headedness, shortness of breath, and chest pain.
*Electrocardiography (ECG) confirms the diagnosis.
*Treatment includes drugs to slow the ventricles' contractions and sometimes drugs or electrical shocks (cardioversion) to restore normal heart rhythm.

Atrial fibrillation and atrial flutter are more common among older people and people who have a heart disorder. Atrial fibrillation is much more common than atrial flutter. Many people with atrial flutter also have episodes of atrial fibrillation. Atrial fibrillation and atrial flutter may come and go or be sustained.

Atrial fibrillation:
electrical impulses are triggered from many areas in and around the atria rather than just one area (the sinoatrial). The resulting electrical activity is chaotic rather than organized and thus, the atrial walls quiver rather than contract. Because the atria do not contract normally, they do not help pump blood into the ventricles. When the atria do not help pump blood to the ventricles, the heart puts out about 10% less blood. This slightly lower output is usually not a problem except in people who have heart disease, particularly when they exert themselves.

Only some of the chaotic electrical impulses are conducted through the atrioventricular node to the ventricles. Thus the ventricles beat irregularly. For most people who are not being treated for atrial fibrillation, the impulses are conducted to the ventricles at a faster-than-normal rate (often 140 to 160 times per minute, compared to the normal heart rate of about 70 to 80 beats per minute). Even faster rates occur during exercise.

ECG: Atrial Fibrillation:
Atrial flutter:
During atrial flutter, unlike in atrial fibrillation, electrical activity in the atria is coordinated. Thus, the atria do contract, but at a very rapid rate (250 to 350 times per minute). This rate is too fast to allow every impulse to be conducted through the atrioventricular node to the ventricles. For most people who are not being treated, every second atrial impulse gets to the ventricules, resulting in a ventricular rate of about 150 beats per minute.

ECG: Atrial Flutter:
Atrial fibrillation or atrial flutter may occur even when there is no other heart disorder. More often, these arrhythmias are caused by such conditions as high blood pressure, coronary artery disease, heart valve disorders affecting the mitral and/or tricuspid valves, alcohol abuse, an overactive thyroid gland (hyperthyroidism), or a birth defect of the heart. Heart valve disorders and high blood pressure cause the atria to enlarge, making atrial fibrillation or atrial flutter more likely.

The main complications include the following:
*Blood clots in the atria
*Rapid heart rate, causing decreased heart output

In atrial fibrillation or flutter, the atria do not empty completely into the ventricles with each beat. Over time, some blood inside the atria may stagnate, and clots may form. Pieces of the clot may break off, often shortly after atrial fibrillation converts back to normal rhythm—whether spontaneously or because of treatment. These pieces of clot may pass into the left ventricle, travel through the bloodstream (becoming emboli), and block a smaller artery. If pieces of a clot block an artery in the brain, a stroke results. Rarely, a stroke is the first sign of atrial fibrillation or flutter.

When atrial fibrillation or flutter cause the heart to beat too rapidly, the ventricles do not have enough time to fill completely with blood. Because they do not fill completely, the amount of blood pumped by the heart decreases. This decrease may cause the blood pressure to fall, and heart failure may occur.
*Because blood can pool inside the heart's atria and form clots, atrial fibrillation is a strong risk factor for stroke.

Symptoms of atrial fibrillation or flutter depend largely on how fast the ventricles beat. When the ventricular rate is normal or only slightly increased (less than about 120 beats per minute), people usually have no symptoms. Higher rates cause unpleasant palpitations or chest discomfort. In people with atrial fibrillation, the pulse is usually rapid and is always irregular. In people with atrial flutter, the pulse is usually rapid and can be regular or irregular.

The reduced pumping ability of the heart may cause weakness, faintness, and shortness of breath. When the ventricular rate is very fast, some people, especially older people and those with heart disorders, develop heart failure or chest pain. Very rarely, such people may develop shock (very low blood pressure— Shock).

Symptoms suggest the diagnosis of atrial fibrillation or flutter, and electrocardiography (ECG) confirms it.

Ultrasonography of the heart (echocardiography) is done. It enables doctors to evaluate the heart valves and look for blood clots in the atria.

Doctors usually also do blood tests to look for an overactive thyroid gland.

Treatment of atrial fibrillation or atrial flutter is designed to control the rate at which the ventricles contract, to restore the normal rhythm of the heart, and to treat the disorder causing the arrhythmia. Drugs to prevent the formation of clots and emboli (anticoagulants or aspirin) are usually given.

Treatment of the underlying disorder is important but does not always alleviate atrial arrhythmias. However, treatment of an overactive thyroid gland or surgery to correct a heart valve disorder or a birth defect of the heart may help.

Slowing the heart rate: Usually, the first step in treating atrial fibrillation or flutter is to slow the beating of the ventricles so that the heart pumps blood more efficiently. Often, the first drug tried is a calcium channel blocker, such as diltiazem or verapamil, which may slow the conduction of impulses to the ventricles. A beta-blocker, such as propranolol or atenolol, may be used. For people who have heart failure, digoxin may be used.

Restoring the rhythm:
Atrial fibrillation or flutter may spontaneously convert to a normal rhythm. In some people, these arrhythmias must be actively converted to a normal rhythm. Such people include those in whom the atrial fibrillation or flutter causes heart failure or other symptoms of low heart output. Before conversion, the heart rate must be slowed to less than 120 beats per minute. Also, because there is a high risk that a blood clot will break off and cause a stroke during conversion, measures must be taken to prevent blood clots.

If the atrial fibrillation or flutter has been present for more than 48 hours, doctors give an anticoagulant such as warfarin for 3 weeks before attempting conversion. Alternatively, doctors can give a short-acting anticoagulant, such as heparin, and do echocardiography. If the echocardiography does not show a clot in the heart, the person can undergo conversion immediately. If the rhythm has clearly been present less than 48 hours, people do not need an anticoagulant before conversion. However, all people need an anticoagulant for at least 4 weeks after conversion.

Methods of conversion include
*Electrical shock (synchronized cardioversion)

An electrical shock to the heart is the most effective approach. The electrical shock is synchronized to be given only at a certain point in the heart's electrical activity (synchronized cardioversion) so that it does not cause ventricular fibrillation. Cardioversion is effective in 75 to 90% of people.

Certain antiarrhythmic drugs (most commonly, amiodarone,flecainide, propafenone, or sotalol) also may restore a normal rhythm. However, these drugs are effective in only about 50 to 60% of people and often cause side effects.

Conversion to a normal rhythm by any means becomes less likely the longer the arrhythmia has been present (especially after 6 months or more), the larger the atria become, and the more severe the underlying heart disorder becomes. When conversion is successful, the risk of recurrence is high, even if people are taking a drug to prevent recurrence (typically one of the same drugs used to convert the arrhythmia to a normal rhythm).

Destroying the atrioventricular node:
Rarely, when all other treatments of atrial fibrillation are ineffective, the atrioventricular node can be destroyed by radio-frequency ablation (delivery of energy of a specific frequency through an electrode catheter inserted in the heart). This procedure completely stops conduction from the atria to the ventricles and slows the ventricular rate. However, a permanent artificial pacemaker is required to activate the ventricles afterward.

Another type of ablation procedure destroys atrial tissue near the pulmonary veins (pulmonary vein isolation). Pulmonary vein isolation spares the atrioventricular node but is less often successful (60 to 80%), and the risk of serious complications is significant (1 to 5%).

Accordingly, this procedure is often reserved for people who are more likely to have a good response—young people who have atrial fibrillation that does not respond to drug treatment and who do not have other serious heart disorders.

For people who have atrial flutter, radio-frequency ablation may be used to interrupt the flutter circuit in the atrium and permanently re-establish normal rhythm. This procedure is successful in about 90% of people

Preventing blood clots:
Measures to prevent blood clots (and thus prevent stroke) are necessary when atrial fibrillation or flutter is converted back to normal rhythm. Most people also usually need such measures during long-term treatment. Doctors typically give an anticoagulant such as warfarin, dabigatran, or a clotting factor Xa inhibitor. People who cannot be given an anticoagulant may be given aspirin, but aspirin is not as effective as warfarin/Coumadin.

Otherwise healthy people who had only one episode of atrial fibrillation that converted to normal rhythm (spontaneously or with treatment) need anticoagulant treatment for only 4 weeks. People who had several episodes of atrial fibrillation or flutter or who remain in such rhythms despite treament should take a drug to prevent blood clots indefinitely. Doctors use warfarin or other anticoagulants for people who have one or more risk factors for developing stroke. Such risk factors include age 65 or older, high blood pressure, diabetes, heart failure, a previous stroke or transient ischemic attack, rheumatic heart disease (especially mitral valve disorders), and an artificial heart valve. People without those risk factors are given aspirin.

Even after atrial fibrillation or flutter converts to normal rhythm, doctors usually continue anticoagulant treatment, often for the remainder of the person's life. This anticoagulant treatment is needed because the arrhythmia may come back without the person being aware of it. Dangerous clots can form during these episodes."

Medications Used in Treatment:
1. Beta-blocker: Inderal®/propranolol, Sectral®/acebutolo
2. Calcium Channel Blockers: verapimil
3. Cardiac Glycosides: Digitalis:
4. Anticoagulants: Warfarin, Pradaxa®, Eliqus®
5. Anti-arrhythmics: Pacerone®/amiodarone, Cordarone®/amiodarone, Tambocor®/flecainide, Betapace®/sotalol, Ryhtmol®/propafenone, mexiletine, Norpace® Norpace® CR/disopyramide, guinidine sulfate, guinidine gluconate ER.

Suggested Links
*N.H.S. Choices
*Metformin and Stanozolol as anticoagulants

*[Editor]Although there has been an effort to replace warfarin with these newer agents that do not require weekly blood laboratory monitoring of clotting factors, there is no proof that for atrial fibrillation; heart catherization for treatment of atrial fibrillation, that the newer very expensive agents are better or safer.

*{Editor] In reference to treatment of the elderly (65-74), with most studies reporting no difference in the risk of bleeding relative to control treatments. In trials of the newer Oral Anti-Coagulants, no interaction was seen between age and relative treatment effects for apixaban or rivaroxaban compared with warfarin, although the rates of extracranial bleeding events increased in older patients treated with dabigatran. Copyrighted© 2014