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Dx Chronic Granulomatous Disease Treatment:

Chronic Granulomatous Disease

The Merck Manual Home Edition states that:
"Chronic granulomatous disease is a hereditary immunodeficiency disorder in which phagocytes (a type of white blood cell) malfunction. Normally, phagocytes (neutrophils, eosinophils, monocytes, and macrophages) ingest and kill microorganisms. In chronicgranulomatousdisease, phagocytes can ingest but cannot produce the substances (such as hydrogen peroxide and superoxide) that kill certain bacteria and fungi. This disorder usually affects boys. Symptoms usually first appear during early childhood but sometimes not until adolescence. Chronic infections occur in the skin, lungs, lymph nodes, mouth, nose, and intestines. Pockets of pus (abscesses) can develop around the anus and in the lungs, bones, and liver. The lymph nodes tend to fill with bacteria and enlarge. The skin over the lymph nodes may break down. As a result, the abscess drains. The liver and spleen enlarge. Children may grow slowly. To diagnose the disorder, doctors take a sample of blood and send it to a laboratory, which measures the activity of phagocytes in response to microorganisms."

Medications Used in Treatment:
1. Interferon Gammas: Actimmune
2. Antibiotics: sulfamethozole/trimetoprim

Suggested Links:
*American Academy of Allergy Asthma & Immunology

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