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Diabetes Treatment of Adult (Type II) Treatment: Read More...


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Consensus:
Background:More than 60 years ago, Jens Moller, M.D. in Denmark documented reversal of diabetic disease in 10,000 individuals using testosterone injections. D. Kapoor at the Andrology Group in Sheffield England and the Bayer Pharmaceutical Group in Switzerland did likewise. Although the weekly injections of testosterone's effect are known to all diabetologists, no one uses this simple, inexpensive treatment as primary intervention.
Research: 18 years ago, the author and leading diabetologist, professor James Sowers, M.D. performed a study of almost 75 diabetic men. The 15 on insulin reduced their requirements by 50%, after starting weekly testosterone injections. The men on oral therapy were able to stop their medication and experience much better glycemic (sugar) control.
Cause and Effect The Air Force Ranch Hand Study showed that close exposure to Agent Orange (Dioxin and DDT) increased their risk of diabetes by 33% compared to the non-exposed commanders on the base.
Treatment has been improved by adding Nandrolone and Stanozolol to the weekly low dose testosterone injections. We hypothesize that this result is because of the potential for the combination of nandrolone and stanozolol to block out the environmental toxins so called xeno-estrogens.
Potential: There are 35 million diabetics in the United States and 250 million in the world. One in three children born here will become diabetic. The costs to the U.S. is almost $300 billion dollars annually while the cost of these three medications is less than $50 per month. Case Report:
[Editor]
Testimonial 'Ernie' has diabetes as have had his mother and most of his obese family members. But 'E' was a super athlete: he knew how to eat and how to train. He saw his regular doctor regularly and still had a glycogenated hemoglobin over 11 (normal is less than 6). He was not recognized as an insulin requiring adult diabetic until the insulin glucose tolerance test was performed. He suffered with low-T and starting the initial testosterone injections brought his hemoglobin A1c down to 7.8. When he spiked up to 10 again, he was ready to start insulin. Using just 4 units of regular insulin with meals brought his glycogenated hemoglobin as low as 6.8. If he sticks to his diet and exercise, he remains under 7; if he does not diet, he goes back up to 7.8. Reducing his glycogenated hemoglobin from 11 to 7 reduces his risk of serious diabetic complications by 75% or more.
Observation
:
Adult Onset Diabetes (Type II)

The Merck Manual states:
"Diabetes mellitus is a disorder in which blood sugar (glucose) levels are abnormally high because the body does not produce enough insulin to meet its needs.

Urination and thirst are increased, and people lose weight when they are not trying to.
Diabetes damages the nerves and causes problems with sensation.
Diabetes damages blood vessels and increases the risk of heart attack, stroke, and kidney failure.

Doctors diagnose diabetes by measuring blood sugar levels.
People with diabetes need to follow a diet that is low in carbohydrates and fat, exercise, and usually take drugs to lower blood sugar levels.

Diabetes is a disorder that affects the amount of sugar in the blood. There are many types of sugar. Some sugars are simple, and others are more complex. Table sugar (sucrose) is made of two simpler sugars called glucose and fructose. Milk sugar (lactose) is made of glucose and a simple sugar called galactose. The carbohydrates in bread, pasta, rice, and similar foods are long chains of different simple sugar molecules. Sucrose, lactose, carbohydrates, and other complex sugars must be broken down into their component simple sugars by enzymes in the digestive tract before the body can absorb them. Once the body absorbs simple sugars, it usually converts them all into glucose, which is the main source of fuel for the body. Glucose is the sugar that is transported through the bloodstream and taken up by cells. Blood "sugar" really means blood glucose.

Insulin, a hormone released from the pancreas, controls the amount of glucose in the blood. Glucose in the bloodstream stimulates the pancreas to produce insulin. Insulin allows glucose to move from the blood into the cells. Once inside the cells, glucose is converted to energy, which is used immediately, or the glucose is stored as fat or glycogen until it is needed.

The levels of glucose in the blood vary normally throughout the day. They rise after a meal and return to normal within about 2 hours after eating. Once the levels of glucose in the blood return to normal, insulin production decreases. The variation in blood glucose levels is usually within a narrow range, about 70 to 110 milligrams per deciliter (mg/dL) of blood in healthy people. If people eat a large amount of carbohydrates, the levels may increase more. People older than 65 years tend to have slightly higher levels, especially after eating.
If the body does not produce enough insulin to move the glucose into the cells, or if the cells stop responding normally to insulin, the resulting high levels of glucose in the blood and the inadequate amount of glucose in the cells together produce the symptoms and complications of diabetes.

Doctors often use the full name diabetes mellitus, rather than diabetes alone, to distinguish this disorder from diabetes insipidus, a relatively rare disorder that does not affect blood glucose levels but also causes increased urination."

Medications Used in Treatment:
1. Biguanides: Glucophage®/metformin
2. Insulin: Novolog®, Humulin®, Lantus®
3. Sulfonylureas:glipizide, gyburide
4. Pioglitazone: Actos®, Avandia®
5. Miscellaneous
6. Liraglutide:
7. Acarbose:
8. Prandin®:
9. Anabolic Steroids

[Editor] PODCAST focus on Diabetes in Adult Men

Suggested Links
N.H.S. Choices
Medscape

[Editor]: See Breakthrough in Diabetes: Lecture Series

[Editor] Insulin is by injection. The literature [about oral hypoglycemic agents] is clear: "The evidence supports use of metformin as a first-line agent. Comparisons of two-drug combinations showed little to no difference in HbA1c reduction, but some combinations increased risk for hypoglycemia and other adverse events." These high priced medications [Actos®, Avandia®, Januvia®, Victoza® and others] do very little to improve glycemic control or lower glycogenated hemoglobin. In any way, the drop of glycogenated hemoglobin with testosterone treatment in men is superior and should be a mainstay of treatment as it improves survival. Testosterone cypionate costs about $44.00 for 10-12 weeks of treatment of 1/2ml IM every 5 days.

[Editor]: With the cost of fasting insulin, fasting glucose and hemoglobin A1c blood laboratory tests less than $20 (twenty dollars), everyone could be screened for diabetes.

Copyrighted June 2014©