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Dx Crohn's Disease, Dx Ulcerative Colitis, Dx IBD Treatment: Read More...

Inflammatory Bowel (Crohn's) Disease

The Merck Manual Home Edition states:
"In inflammatory bowel diseases, the intestine (bowel) becomes inflamed, often causing recurring abdominal cramps and diarrhea. The two primary types of inflammatory bowel disease (IBD) are Crohn's disease and ulcerative colitis. These two diseases have many similarities and sometimes are difficult to distinguish from each other. However, there are several differences. For example, Crohn's disease can affect almost any part of the digestive tract, whereas ulcerative colitis almost always affects only the large intestine. The cause of these diseases is not known but may involve an abnormal immune reaction to intestinal bacteria or other agents in people with a genetic predisposition.

IBD affects people of all ages but usually begins before age 30, typically from age 14 to 24. IBD is most common among people of Northern European and Anglo-Saxon descent and is 2 to 4 times more common among Ashkenazi Jews. Both sexes are equally affected. First-degree relatives (mother, father, sister, or brother) of people with IBD have a 4- to 20-fold increased risk of developing IBD.

The symptoms caused by IBD vary depending on which part of the intestine is affected and whether the person has Crohn disease or ulcerative colitis. People with Crohn disease usually have chronic diarrhea and abdominal pain. People with ulcerative colitis usually have intermittent episodes of abdominal cramps and bloody diarrhea. People with longstanding diarrhea may lose weight and develop symptoms of vitamin deficiency."

Medications Used in Treatment:
1. Corticosteroids®:
2. Aminosalicylates: Azulfidine®, Asacol®HD, Lialda®
3. TNF Blockers: Humina®, Cimzia®, Remicade®
4. Danazol:
6. Anabolic Steroids: Testosterone, Oxandrin®, Nandrolone, Stanozolol
7. Human Growth Hormone: Tev-Tropin®

*[Editor] Testimonial: JC had suffered with Crohn's Disease since his teen years. He had had 30 bowel surgeries, each one leaving him weaker and unable to work. He dropped to less than 130 pounds. The older medications such as methotrexate and imuran, as well as the newest biologic medications such as Remicade® had been ineffective. The Editor started him on the program for individuals with the most severe disease: four (4) anabolic steroids and human growth hormone. He gained almost 40 pounds in the first year and has been able to return to work.

Suggested Links
* N.H.S. Choice
* Medscape on Risk Factors

[Editor]: This article confirmed what we have been saying for 20 years
A 2015 article from the Journal of Hormone Molecular Biology Investigation reports of a long-term observational study of 92 men with Crohn's Disease treated with 1000mg of testosterone for 12 weeks, and up to 7 years. They reported a 75% reduction in the Crohn's disease Activity Index a P factor of <0.0001 (where .05 is considered significant. "There were not significant side effects on testosterone"./a>

Because testosterone deficiency affects more than 50% of men with Crohn's disease (osteoporosis 17%, osteopenia 29%, low testosterone 6%), we have treated these IBD Case Reports with injections of testosterone. Others report that 6-months of testosterone injections cause "the inflammatory markers, IL-1β, TNF-α and CRP [to be] decreased, while IL-6 and IL-10 did not change significantly". Spanish researchers confirmed that Remicade® (infliximab) reduced the higher concentrations of TNF and IL-1Beta found in UC patients. Interestingly, again In animal studies testosterone  protected against increases in TNF.

*[Editor]: The point to be made is that testosterone specifically effects the inflammatory markers of IBD in the same positive way that Remicade® does at one-fiftieth the cost and without the listed serious risk factors.
Human Growth Hormone has been used in our most severe IBD Cases. Northwestern University researchers noted that preliminary studies using recombinant growth factors seem promising in IBD preclinical and clinical trials." One recent 18 year old male Case Report has been in remission for 5 years. A recent Case Report allowed an African-American male to discontinue Remicade®. If only for their anabolic effect, anabolic steroids (AS) warrant an initial trial in IBD males to treat the comorbidity of malnutrition, wasting, muscle and bone loss associated with IBD. AS and hGH, when effective, are a cost-effective alternative to TNF Blockers, costing less than one-tenth as much.

**[Editor] It has been known for more than 15 years that hGH improves the quality of life of those with a shortened bowel. The Cochrane Database Review found support for "Byrne and colleagues reported enhanced absorption of nutrients, improved weight gain, and reduction in parenteral nutrition requirements with the administration of a combination of human growth hormone (HGH) and glutamine in patients with short bowel syndrome.... Human growth hormone with or without glutamine appears to provide benefit in terms of increased weight.., lean body mass .. energy absorption ..and nitrogen absorption .. for patients with short bowel syndrome."

*[Editor]The Journal of Inflammatory Bowel Disease, 2013, warns that there is evidence that "young male patients with Crohn's disease appear to be at greatest risk (particularly non-Hodgkin's lymphoma). Furthermore, thiopurines and anti-TNF agents are associated with elevated rates of non-melanoma skin cancer in non-IBD and IBD patients, and anti-TNF agents may also increase the risk of melanoma".

*[Editor] The author, Qin, makes a strong point for the elimination of all artificial sweeteners because they disrupt the normal protecctive bacterial coating of the gastro-intestinal tract.
Similiarly, deficiencies of selenium are noted in ulcerative colitis. Speckmann suggested that adequate levels of selenium may counteract chronic intestinal inflammation in humans.
Treatment with n-acetyl cysteine orally or IB glutanthione may be of benefit.

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