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Dx Rheumatoid Arthritis Treatment: Read more...


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Observation:

"Rheumatoid arthritis patients run an increased risk of malignant cancers, independent of biologic and DMARD treatment," researchers report.
Rheumatoid Arthritis

The Merck Manual Home Edition
states:
"Worldwide, rheumatoid arthritis develops in about 1% of the population, regardless of race or country of origin, affecting women 2 to 3 times more often than men. Usually, rheumatoid arthritis first appears between 35 years and 50 years of age, but it may occur at any age. A disorder similar to rheumatoid arthritis can occur in children.
  The exact cause of rheumatoid arthritis is not known. It is considered an autoimmune disease. Components of the immune system attack the soft tissue that lines the joints (synovial tissue) and can also attack connective tissue in many other parts of the body, such as the blood vessels and lungs. Eventually, the cartilage, bone, and ligaments of the joint erode, causing deformity, instability, and scarring within the joint. The joints deteriorate at a variable rate. Many factors, including genetic predisposition, may influence the pattern of the disease. Unknown environmental factors (such as viral infections and cigarette smoking [Editor: environmental toxins?]) are thought to play a role.

Symptoms
  People with rheumatoid arthritis may have a mild course, occasional flare-ups with long periods of remission (in which the disease is inactive), or a steadily progressive disease, which may be slow or rapid. Rheumatoid arthritis may start suddenly, with many joints becoming inflamed at the same time. More often, it starts subtly, gradually affecting different joints. Usually, the inflammation is symmetric, with joints on both sides of the body affected about equally.
  Rheumatoid arthritis can affect any joint, but most often the small joints in the fingers, toes, hands, feet, wrists, elbows, and ankles become inflamed first. Other commonly affected joints include the hips, knees, and shoulders. The inflamed joints are usually painful and often stiff, especially just after awakening...
  Affected joints are often tender, warm, red, and enlarged because of swelling of the soft tissue and sometimes fluid within the joint. Joints can quickly become deformed. Joints may freeze in one position so that they cannot bend or open fully, which leads to a limited range of motion...
  Swollen wrists can pinch a nerve and result in numbness or tingling due to carpal tunnel syndrome (see see Carpal Tunnel Syndrome). Cysts, which may develop behind affected knees, can rupture, causing pain and swelling in the lower legs. Up to 30% of people with rheumatoid arthritis have hard bumps (called rheumatoid nodules) just under the skin, usually near sites of pressure (such as the back of the forearm near the elbow)."

These individuals have a shortened life expectancy by 3 to 7 years. They have more heart disease, more GI bleeding, and 80% develop permanent joing abnormalities within 10 years. Although 3 of 5 find medical treatment relieves symptoms, the disease rarely resolves.

*[Editor]: When viewing the long list of medical treatments it becomes clear that no one has any idea as to the effective treatment that can/will treat the cause.The Editor suggests there is a link into environmental toxins to the human endocrine biochemistry that affects immunology possibly causing disease. We see this accepted link between endometriosis and diabetes. "It is showed that exposure to background levels of chlorinated dioxins and related chemicals through breast milk may cause some immunologic disorder: that this Rheumatoid Disease--in some-- can be reversed must give plausibility of cause (EDCs), resulting in inflammation, and the EDCs can be blocked by mixtures of androgens.

Medications Used in Treatment:
1. NSAIDs: aspirin,Advil®/ibuprofen, Naprosyn® Aleve® Anaprox® DS/naprosyn, Mobic®/ meloxicam, Ansaid®/flurbiprofen, diflunisal,fenoprofen, Celebrex®/celecoxib, diclofenac sodium, nabumetone, indomethacin, butazolidin, etodolac, Feldene®/ piroxicam,ketoprofen,tolmetin, Clinorilv/sulindac, Cataflam®/diclofenac potassium, Dayprov/ oxaprozin
2. Corticosteroids: prednisone, Cortef®/hydrocortisone, dexamethasone Medrol®/methylprednisolone, Prelone® Orapred® Pediapred®/prednisolone sodium phosphate, Kenalog®/triamcinolone, Millipred® Veripred®/prednisolone, Solu-Cortef®/a-hydrocort, Solu-Medrol®/methylprednisolone sodium succinate, Depo-Medrol®/methylprednisolone acetate
3. Antifolates: Rheumatrex® Trexall®/methotrexate
4. Anti-rheumatics
: Plaquenil®(hdyroxychloroquine, Arava®/leflunomide, Cuprimine® Depen®/penicillamine,
5. Antimetabolites: Imuran®/azathioprine, Azasan®/azathiprine, Ridaura®/auranofin
6. TNF Blockers: Humira®/adalimumab, Enbrel®/etanercept, Simponi®/golimumab, Cimzia®/certolizumab, Remicade®/infliximab
7. Aminosalicylates: Azulfidine® E-Tab, sulfasalzine dr
8. CTLA-4 Agonists: Orencia®/abatacept
9. Anti-metabolites: Imuran®/ azathioprine
10. CNI Immunosuppressants: Neoral®/cyclosporine modified, genfraf
11. Kinase Inhibitors: Xeljanz®/ tofacitinib
12. Interleukin Antagonists: Kineret®/anakinra, Actemra®/ tocilizumab
13. Adrenocorticotropic Hormones: H.P. Acthar®/ corticotropin
14. Androgens: testosterone cypionate, nandrolone, oxandrin, stanozolol

Suggested Links:
*N.H.S. Choices (with Video)
*Medscape
*Arthritis Foundation

*[Editor]

Testimonial on I-tunes. "I was brought to the Editor by my friend. I was taking methotexate for my rheumatoid arthritic knees and morphine for pain. I had refused Humira®/ Enbrel®-like medications because of fear of the side-effects. So, when the doctor suggested weekly injections of testosterone/derivatives, I thought I had nothing to lose. I stopped the methotrexate. Within two weeks, I had stopped all pain medications. I realized I did not need to have both my knee joints replaced. My energy and drive returned. I see the doctor yearly for my medication and most importantly, I have my life back."

Rheumatoid Arthritis may respond as well, or better, to a mixture of anabolic steroids compared to the TNF Agonists (biologics). The anti-inflammatory targets of testosterone and the anabolic steroids match almost exactly the cytokines and interleukenes targets of the biologics. Mixed anabolic steroids cost less than 1/50th that of the biologics. Logically, if the anabolics were considered first in trial for 8-16 weeks, the patient and physician could evaluate whether the biologics would be, in fact, necessary. Learn about the dosages from the CME Video.

*[Editor]: 70% of Rheumatoid arthritis patients have rheumatoid factor (antibodies) in their blood. 90% have positive sedimentation rates. High C-reactive protein is a sign of inflammation. Many are anemic. These laboratory tests are inexpensive and can be ordered On-Line.

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