Curing the World One Patient at a Time
TOLL FREE: 855.251.9116

Dx Sjogren's Disease Treatment:

Sjogren's Syndrome

The Merck Manual Home Edition
"Sjögren syndrome is common and characterized by excessive dryness of the eyes, mouth, and other mucous membranes.

*White blood cells can infiltrate and damage glands that secrete fluids, and sometimes other organs can be damaged.
*Tests can be done to measure gland function and assess the presence of abnormal antibodies in the blood.
*Usually, measures to keep surfaces such as the eyes and mouth moist are sufficient. *Rarely, when internal organ damage is severe, corticosteroids, cyclophosphamide, or rituximab can be given by mouth.

Sjögren syndrome is thought to be an autoimmune disorder, but its cause is not known. It is most common among middle-aged women. Some people with Sjögren syndrome also have other autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, vasculitis, mixed connective tissue disease, Hashimoto thyroiditis, primary biliary cirrhosis, and chronic autoimmune hepatitis.

White blood cells infiltrate the glands that secrete fluids, such as the salivary glands in the mouth and the tear glands in the eyes. The white blood cells injure the glands, resulting in a dry mouth and dry eyes—the hallmark symptoms of this syndrome.

In some people, only the mouth or eyes are dry (a condition called sicca complex or sicca syndrome). Dryness of the eyes may severely damage the cornea, resulting in a scratchy or irritated sensation, and a lack of tears can cause permanent eye damage. Insufficient saliva in the mouth can dull taste and smell, make eating and swallowing painful, and can cause dental cavities and salivary gland stones. The salivary glands in the cheeks (parotids) become enlarged and slightly tender in about one third of people. The mouth may also burn, which may sometimes indicate a complicating yeast infection. Hair loss may occur.

In other people, many organs are affected. Sjögren syndrome can dry out the mucous membranes lining the nose, throat, digestive tract, voice box (larynx), windpipe (trachea), airways of the lungs, vulva, and vagina. Dryness of the vulva and vagina can make sexual intercourse painful. Dryness of the trachea can cause cough. Nerve, lung, and other tissues may be damaged by the inflammation.

Joint inflammation (arthritis) occurs in about one third of people, affecting the same joints that rheumatoid arthritis affects, but the joint inflammation of Sjögren syndrome tends to be milder and is usually not destructive. Lymph nodes may enlarge throughout the body. Lymphoma, a cancer of the lymphatic system, is more common among people who have Sjögren syndrome than the general population, and people develop non-Hodgkin lymphoma at 40 times the normal rate. Rarely, rashes, kidney damage, Raynaud phenomenon, or vasculitis that causes damage to the peripheral nerves occurs.

Although a sensation of dry mouth or dry eyes is fairly common, a sensation of dry mouth and dry eyes accompanied by joint inflammation, enlarged salivary glands, nerve damage, certain rashes, or kidney problems may indicate that the person has Sjögren syndrome. Various tests can help a doctor diagnose this disorder and differentiate it from other disorders that can cause similar symptoms.

The amount of tears produced can be estimated by placing a filter paper strip under each lower eyelid and observing how much of the strip is moistened (Schirmer test). A person who has Sjögren syndrome may produce less than one third of the normal amount. An ophthalmologist can test for damage to the eye's surface. Infrequently, more sophisticated tests to evaluate salivary gland secretion may be done, and a doctor may order scans or the removal of tissue for examination and testing (biopsy) of the salivary glands.
,br> Blood tests can detect abnormal antibodies, including SS-A, an antibody that is present in people who have Sjögren syndrome. Antinuclear antibodies (which are found in people with lupus) and rheumatoid factor (which is found in people with rheumatoid arthritis) can also be found in people with Sjögren syndrome. The erythrocyte sedimentation rate (ESR), a test that measures the rate at which red blood cells settle to the bottom of a test tube containing blood, is elevated in about 70% of people. About 33% of people have a decreased number of red blood cells (anemia), and up to 25% of people have a decreased number of certain types of white blood cells (leukopenia).

Prognosis and Treatment:
The prognosis is generally good. However, if the lungs, kidneys, or lymph nodes are damaged by the antibodies, pneumonia, kidney failure, or lymphoma may result.

No cure for Sjögren syndrome is available, but symptoms can be relieved. Dry eyes can be treated with artificial tear drops during the day and a lubricating ointment at night. A prescription eye drop containing cyclosporine can also be used. Shields can be fitted on the sides of glasses, helping to protect the eyes from air and wind, reducing evaporation of tears. A simple surgical procedure called punctal occlusion can be performed. In this procedure, an ophthalmologist inserts small plugs into the tear ducts in the corner of the lower eyelid, so the person's tears stay on the eye longer.

A dry mouth can be moistened by continuously sipping liquids, chewing sugarless gum, or using a saliva substitute mouth rinse. Drugs that reduce the amount of saliva, such as decongestants, antidepressants, and antihistamines, should be avoided because they can worsen the dryness. The drugs pilocarpine or cevimeline may help stimulate the production of saliva if the salivary glands are not too severely damaged. Using a vaginal lubricant can very effectively reduce pain caused by sexual intercourse.

Fastidious dental hygiene and frequent dental visits can minimize tooth decay and loss. Painful, swollen salivary glands can be treated with analgesics and warm compresses. Doctors remove stones in the salivary glands. Because joint symptoms are usually mild, treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) and rest is often sufficient. Antimalarial drugs (such as hydroxychloroquine) can relieve joint pain, swollen lymph nodes, and skin problems. Very rarely, the drug methotrexate may be given. When symptoms resulting from damage to internal organs are severe, corticosteroids (such as prednisone), cyclophosphamide, or rituximab taken by mouth may be given.

Sjögren syndrome that occurs along with other autoimmune diseases, such as lupus, rheumatoid arthritis, and systemic sclerosis, is referred to as secondary Sjögren syndrome. People with secondary Sjögren syndrome receive additional treatment for the other disease."

Medications Used in Treatment:
1. Dry Eyes: CNI Immunosuppressants: Restasis
Dry Mouth: Salivation Agents: Salagen/ pilocarpine
3. Pain: Non-Steroidal Anti-inflammatory Drugs: (NSAIDs)
4. Associated Autoimmune diseases:
   DMARDs: Methotrexate
   TNF Inhibitors: Humira
   Mixed Anabolic Steroids: Testosterone, Nandrolone, Oxandrin, Stanozolol

Copyrighted 2014©