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Dx Peripheral Artery Disease Treatment:

Peripheral Arterial Disease

The Merck Manual Home Edition
"Peripheral arterial disease results in reduced blood flow in the arteries of the trunk, arms, and legs.

Most often, doctors use the term peripheral arterial disease to describe poor circulation in the arteries of the legs that results from atherosclerosis. However, peripheral arterial disease can affect other arteries and can have other causes. Disorders affecting arteries that supply the brain are considered separately as cerebrovascular disease.

Peripheral arterial disease may be described as occlusive or functional. Occlusive peripheral arterial disease is due to structural changes that narrow or block arteries. Functional peripheral arterial disease is usually due to a sudden temporary narrowing (spasm) or, rarely, to a widening (vasodilation) of arteries."

Medications Used in Treatment:
1. Antiplatelet Drugs: Plavix®/clopidogrel
2. Blood Viscosity Reducers: pentoxifylline
3. PDE3 Inhibitors: Pletal®/cilistazol
4. Beta Agonists: isoxsuprine

Suggested Links:
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*[Editor] "In men, testosterone (T) levels decline with age, and lower T predicts all-cause and cardiovascular mortality...Lower T or DHT levels, but not E2, are associated with symptoms of intermittent claudication in older men. Reduced exposure to androgens may represent a causal factor or biomarker for symptomatic peripheral arterial disease. Further studies are needed to examine underlying mechanisms and evaluate therapeutic options in ageing men."

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